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GNL2 Antibody

  • 货号：
    CSB-PA009624GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q13823
  • 基因名：
    GNL2
  • 别名：
    Autoantigen NGP-1 antibody; Autoantigen NGP1 antibody; DJ423B22.6 (novel nucleolar guanosine 5'-triphosphate binding protein antibody; FLJ40906 antibody; GNL2 antibody; Guanine nucleotide binding protein-like 2 (nucleolar) antibody; HUMAUANTIG antibody; NGP1 antibody; NOG2_HUMAN antibody; novel nucleolar guanosine 5'-triphosphate binding protein autoantigen antibody; nucleolar G-protein gene 1 antibody; Nucleolar GTP binding protein 2 antibody; Nucleolar GTP-binding protein 2 antibody; Nucleolar GTPase antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Human GNL2
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. May promote cell proliferation possibly by increasing p53/TP53 protein levels, and consequently those of its downstream product CDKN1A/p21, and decreasing RPL23A protein levels.
  • 基因功能参考文献：
    1. NGP-1 promotes cell cycle progression through the activation of the p53/p21(Cip-1/Waf1) pathway. PMID: 26203195
    2. GNL2 and SEC13 are required for nonsense-mediated mRNA decay pathway in human cells. PMID: 25452588
  • 亚细胞定位：
    Nucleus, nucleolus.
  • 蛋白家族：
    TRAFAC class YlqF/YawG GTPase family, NOG2 subfamily
  • 组织特异性：
    Widely expressed, with the highest expression level in testis.
  • 数据库链接：

    HGNC: 29925

    OMIM: 609365

    KEGG: hsa:29889

    STRING: 9606.ENSP00000362153

    UniGene: Hs.75528