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GOLGA3 Antibody

  • 货号：
    CSB-PA009646GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q08378
  • 基因名：
  • 别名：
    GOLGA3Golgin subfamily A member 3 antibody; Golgi complex-associated protein of 170 kDa antibody; GCP170 antibody; Golgin-160 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Human GOLGA3
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IF
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Golgi auto-antigen; probably involved in maintaining Golgi structure.
  • 基因功能参考文献：
    1. The golgin-160 binds directly to the third intracellular loop of beta1AR and that this binding depends on three basic residues in this loop. PMID: 24566136
    2. Golgi protein golgin160 recruits dynein to Golgi membranes. PMID: 22814606
    3. A common epitope of proteins golgin-160, voltage-gated potassium channel and disulfide isomerase was identified by screening with autoantibodies of a type 1 diabetic patient PMID: 20170975
    4. NH2 terminal domain of Golgin 160 has a role in nuclear transport and Golgi apparatus localization PMID: 12130652
    5. results indicate that GCP16 is the acylated membrane protein, associated with GCP170, and possibly involved in vesicular transport from the Golgi to the cell surface PMID: 14522980
    6. Caspase-resistant GOLGA3 disrupts apoptosis induced by secretory pathway stress and ligation of death receptors. PMID: 15829563
    7. golgin-160 assosiates in an isoform-specific manner with the Golgi-associated protein PIST PMID: 15951434
    8. GCP60 interacts preferentially with one of the golgin-160 caspase cleavage fragments (residues 140-311). This strong interaction prevented the golgin-160 fragment from accumulating in the nucleus when this fragment and GCP60 were overexpressed. PMID: 16870622
    9. golgin-160 may promote efficient surface delivery of a subset of cargo molecules PMID: 17118120
    10. nuclear translocation of golgin-160-(140-311) is a highly coordinated event regulated not only by cleavage of the golgin-160 head but also by the oxidation state of GCP60 PMID: 17711851

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  • 亚细胞定位：
    Cytoplasm. Golgi apparatus, Golgi stack membrane; Peripheral membrane protein.
  • 组织特异性：
    Expressed in all tissues tested. Expressed in liver, testis, lung, heart, salivary gland and kidney.
  • 数据库链接：

    HGNC: 4426

    OMIM: 602581

    KEGG: hsa:2802

    STRING: 9606.ENSP00000204726

    UniGene: Hs.507333