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GP9 Antibody

  • 货号：
    CSB-PA009690LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA009690LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human spleen tissue using CSB-PA009690LA01HU at dilution of 1:100
    • Immunofluorescent analysis of A549 cells using CSB-PA009690LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) GP9 Polyclonal antibody
  • Uniprot No.：
    P14770
  • 基因名：
  • 别名：
    GP9; Platelet glycoprotein IX; GP-IX; GPIX; Glycoprotein 9; CD antigen CD42a
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Platelet glycoprotein IX protein (17-88AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，GP9 Antibody (CSB-PA009690LA01HU)，的标记方式是Non-conjugated。对于GP9 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA009690LB01HU GP9 Antibody, HRP conjugated ELISA
    FITC CSB-PA009690LC01HU GP9 Antibody, FITC conjugated
    Biotin CSB-PA009690LD01HU GP9 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis. GP-IX may provide for membrane insertion and orientation of GP-Ib.
  • 基因功能参考文献：
    1. Case Report: suggest that alloantibodies directed against Cab4b, the first human platelet antigen carried by glycoprotein IX, can induce severe neonatal thrombocytopenia. PMID: 28561420
    2. factor XI is localized to GPIb in membrane rafts and this association is important for promoting the activation of factor XI by thrombin on the platelet surface PMID: 12517745
    3. Raft association and cytoskeletal linkage of the platelet GPIb-IX-V complex are interrelated and are required for optimal receptor function, by attracting signaling proteins and membrane skeletal association allows proteins to move to new locations. PMID: 19874464
    4. the putative convex surface of the LRR domain in GPIX is sufficient, in the context of full-length subunit, to mediate its association with GPIbbeta PMID: 19566547
    5. Novel nonsense mutation is associated with Bernard-Soulier syndrome. PMID: 12447957
    6. findings indicate that the Ala14-->Thr mutation in the transmembrane region of GP IX does not induce intracellular GP Ib/IX complex degradation, but prevents its insertion in the cytoplasmic membrane of platelets and CHO cells PMID: 15351858
    7. the first non-Caucasian Turkish Bernard-Soulier syndrome case due to GPIX N45S and is likely the result of a recurrent mutational event. PMID: 17804902
    8. Findings point to a role of the GPIb-V-IX complex intrinsic to megakaryocytes at the stage of proplatelet formation and suggest a functional link with the underlying microtubular cytoskeleton in platelet biogenesis. PMID: 19377075
    9. Homozygous missense mutation in position 1829 (A(R)G) of the GPIX gene causes Bernard-Soulier syndrome in a Swiss family. PMID: 19404517

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  • 相关疾病：
    Bernard-Soulier syndrome (BSS)
  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 数据库链接：

    HGNC: 4444

    OMIM: 173515

    KEGG: hsa:2815

    STRING: 9606.ENSP00000303942

    UniGene: Hs.1144