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GPC Antibody

  • 货号：
    CSB-PA357830LA01LKW
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 其他：

产品详情

  • 产品描述：

    The GPC antibody is a polyclonal rabbit antibody that targets the Lymphocytic choriomeningitis virus GPC. It is produced in rabbits and its immunogen is a synthetic peptide that corresponds to the amino acids 266-498 of the recombinant Lymphocytic choriomeningitis virus Pre-glycoprotein polyprotein GP complex protein. The antibody has been purified by protein G affinity chromatography and has a purity level greater than 95%. It is of the IgG class, unconjugated, and in liquid form. The ptxA antibody is capable of reacting with the Lymphocytic choriomeningitis virus GPC and has been validated in ELISA.

    The pre-glycoprotein polyprotein GPC protein of Lymphocytic choriomeningitis virus (LCMV) is involved in the assembly and maturation of the virus particles. It is responsible for the formation of the virion spike and mediates virus attachment and entry into host cells. Additionally, it is essential for the replication of the virus and plays a critical role in the pathogenesis of LCMV infection.

  • 产品名称：
    Rabbit anti-Lymphocytic choriomeningitis virus GPC Polyclonal antibody
  • Uniprot No.：
    P09991
  • 基因名：
    GPC
  • 别名：
    GPC; GP-C; Segment; S; Pre-glycoprotein polyprotein GP complex; Pre-GP-C
  • 宿主：
    Rabbit
  • 反应种属：
    Lymphocytic choriomeningitis virus
  • 免疫原：
    Recombinant Lymphocytic choriomeningitis virus Pre-glycoprotein polyprotein GP complex protein (266-498AA)
  • 免疫原种属：
    Lymphocytic choriomeningitis virus
  • 标记方式：
    Non-conjugated

    本页面中的产品，GPC Antibody (CSB-PA357830LA01LKW)，的标记方式是Non-conjugated。对于GPC Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA357830LB01LKW GPC Antibody, HRP conjugated ELISA
    FITC CSB-PA357830LC01LKW GPC Antibody, FITC conjugated
    Biotin CSB-PA357830LD01LKW GPC Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    class I viral fusion protein that directs fusion of viral and host endosomal membranes, leading to delivery of the nucleocapsid into the cytoplasm. Membrane fusion is mediated by irreversible conformational changes induced upon acidification in the endosome.; Stable signal peptide (SSP): cleaved and functions as a signal peptide. In addition, it is also retained as the third component of the GP complex. The SSP is required for efficient glycoprotein expression, post-translational maturation cleavage of GP1 and GP2, glycoprotein transport to the cell surface plasma membrane, formation of infectious virus particles, and acid pH-dependent glycoprotein-mediated cell fusion.; interacts with the host receptor. Mediates virus attachment to host receptor alpha-dystroglycan DAG1. This attachment induces virion internalization predominantly through clathrin- and caveolin-independent endocytosis.
  • 基因功能参考文献：
    1. The viral glycoprotein precursor (GPC)was responsible for the induction of ATF6 regulated branch of the host cell's unfolded protein response. PMID: 21106748
    2. N-linked glycan mutations at positions 87 and 97 on GP1 resulted in reduction of expression and absence of cleavage and were necessary for downstream functions, as confirmed by the loss of GP-mediated fusion activity with T87A and S97A mutants. PMID: 21056893
    3. the LCMV GP is a trimer and must be considered a member of the class I viral fusion protein family PMID: 16731928
    4. The stable signal peptide of the lymphocytic choriomeningitis virus surface glycoprotein precursor is involved in the glycoprotein (GP) precursor expression, processing, cell surface localization, particle formation and GP-mediated fusion. PMID: 17376927
  • 亚细胞定位：
    [Glycoprotein G1]: Virion membrane; Peripheral membrane protein. Host endoplasmic reticulum membrane; Peripheral membrane protein. Host Golgi apparatus membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein.; [Glycoprotein G2]: Virion membrane; Single-pass membrane protein. Host endoplasmic reticulum membrane; Single-pass membrane protein. Host Golgi apparatus membrane; Single-pass membrane protein. Host cell membrane; Single-pass membrane protein.; [Stable signal peptide]: Virion membrane; Multi-pass membrane protein. Host endoplasmic reticulum membrane; Multi-pass membrane protein. Host Golgi apparatus membrane; Multi-pass membrane protein. Host cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Arenaviridae GPC protein family
  • 数据库链接：

    KEGG: vg:956591