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  4. GPD1 Antibody

GPD1 Antibody

  • 货号：
    CSB-PA009709GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    P21695
  • 基因名：
    GPD1
  • 别名：
    AI747587 antibody; cytoplasmic antibody; EC 1.1.1.8 antibody; FLJ26652 antibody; G3PD antibody; Gdc-1 antibody; Gdc1 antibody; Gdp1 antibody; Glycerol 3 phosphate dehydrogenase 1 antibody; Glycerol 3 phosphate dehydrogenase cytosolic antibody; Glycerol 3 phosphate dehydrogenase soluble antibody; Glycerol-3-phosphate dehydrogenase [NAD+] antibody; Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic antibody; Glycerol-3-phosphate dehydrogenase 1 (soluble) antibody; Glycerol-3-phosphate dehydrogenase antibody; Glycerol-3-phosphate dehydrogenase, soluble antibody; Glycerphosphate dehydrogenase antibody; GPD-C antibody; gpd1 antibody; Gpd1 protein antibody; Gpd3 antibody; GPDA_HUMAN antibody; Gpdc antibody; GPDH antibody; GPDH-C antibody; Gpdhc antibody; HTGTI antibody; KIAA4010 antibody; MGC93453 antibody; MGPD antibody; mKIAA4010 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human GPD1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Has glycerol-3-phosphate dehydrogenase activity.
  • 基因功能参考文献：
    1. To recognize this entity by considering GPD1 mutations in appropriate clinical settings. PMID: 27368975
    2. Although these data indicate that a lack of GPD1 inhibits gluconeogenesis from glycerol, chronic GPD1 deficiency may induce an adaptation that enhances gluconeogenesis from glycogenic amino acids PMID: 27733253
    3. The R269A mutation of GPDH1 results in a 110-fold increase in K(m) (2.8 kcal/mol effect) and a 41,000-fold decrease in k(cat) (6.3 kcal/mol effect), which corresponds to a 9.1 kcal/mol destabilization of the transition state. PMID: 25884759
    4. massive hepatomegaly, fatty liver and severe hypertriglyceridemia carrying a compound heterozygous mutation in GPD1 PMID: 24549054
    5. Mutation analysis revealed a homozygous splicing mutation, c.361-1G>C, which resulted in an aberrantly spliced mRNA in the ten affected individuals. PMID: 22226083
    6. The expression levels of the GPD1 gene did not differ between patients with OSA and their matched controls. The results were not affected by the clinical and biochemical measurements, the sleep parameters or the severity of nocturnal hypoxemia. PMID: 20404019
    7. Identification and function of mutations in FAD-binding domain of mitochonrial glycerophosphate dehydrogenase in caucasians with type 2 diabetes mellitus. PMID: 11822825
    8. GPD1 has a role in increased triacylglycerol production in adipose tissue of obese humans PMID: 14674682
    9. The apoenzyme structure of GPD1 has been determined; an electrophilic catalytic mechanism by the epsilon-NH3+ group of Lys204 is proposed on the basis of structural analyses. PMID: 16460752
    10. GpD1 is a weight-loss-responsive gene in skeletal muscle. Its observed transcriptional modulation may decrease triglyceride synthesis, with weight loss. PMID: 16849634
    11. The activities of glycerol phosphate dehydrogenase were decreased by 73% in pancreatic islets of patients with type 2 diabetes. PMID: 19296078
    12. the discovery overexpression of GPD1 and RRBP1 proteins and lack of expression for HNRNPH1 and SERPINB6 proteins which are new candidate biomarkers of colon cancer. PMID: 19425502

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  • 相关疾病：
    Hypertriglyceridemia, transient infantile (HTGTI)
  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    NAD-dependent glycerol-3-phosphate dehydrogenase family
  • 组织特异性：
    Expressed in liver (at protein level).
  • 数据库链接：

    HGNC: 4455

    OMIM: 138420

    KEGG: hsa:2819

    STRING: 9606.ENSP00000301149

    UniGene: Hs.524418