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GPRASP1 Antibody

  • 货号：
    CSB-PA080057
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q5JY77
  • 基因名：
    GPRASP1
  • 别名：
    G-protein coupled receptor-associated sorting protein 1 antibody; GASP antibody; GASP-1 antibody; GASP1 antibody; GASP1_HUMAN antibody; Gprasp1 antibody; KIAA0443 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human GASP-1.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    IHC, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Modulates lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors. Targets receptors for degradation in lysosomes via its interaction with BECN2.
  • 基因功能参考文献：
    1. Study demonstrated that binding of clozapine or olanzapine to the 5-HT7 receptor leads to antagonist-mediated lysosomal degradation by exposing key residues in the C-terminal tail that interact with GASP-1 PMID: 25706089
    2. Data suggest that specific serine/threonine residues in DRD2 (dopamine receptor D2) are involved in regulation of DRD2 endocytosis by GRK2 (G-protein coupled receptor kinase 2) and GASP1. PMID: 23082996
    3. GASP1 was identified as a potential new serum and biomarker for brain, pancreatic, lung, and breast cancers, and gliomas. PMID: 22483848
    4. LIR was able to induce gains in 1RM and quadriceps CSA similar to those observed after traditional HI. These responses may be related to the concomitant decrease in MSTN and increase in FLST isoforms, GASP-1, and SMAD-7 mRNA gene expression. PMID: 21900845
    5. These studies identify GASP-1 as a potential new serum and tumor biomarker for breast cancer. PMID: 21791203
    6. following this endocytosis the D(3) dopamine receptors fail to recycle and are instead targeted for degradation through an interaction with the G protein-coupled receptor (GPCR)-associated sorting protein-1 (GASP-1) PMID: 21030592
    7. This review describes the discovery of GASPs, their major features, interacting partners, functions and possible involvement in pathological situations including neurodegenerative diseases and cancer. PMID: 20394773
    8. identified a protein that binds preferentially to the cytoplasmic tail of the delta opioid receptor as a candidate heterotrimeric GTP-binding protein (G protein)-coupled receptor-associated sorting protein (GASP) [GASP] PMID: 12142540
    9. Modulation of the D2-GASP interaction is important for the functional down-regulation of D2 dopamine receptors. PMID: 16049099

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    GPRASP family
  • 组织特异性：
    Expressed in the brain, with lower expression in medulla, spinal cord and substantia nigra.
  • 数据库链接：

    HGNC: 24834

    OMIM: 300417

    KEGG: hsa:9737

    STRING: 9606.ENSP00000355146

    UniGene: Hs.729265