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GPT2 Antibody

  • 货号：
    CSB-PA823460LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: U87 whole cell lysate
      All lanes: GPT2 antibody at 4.5µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 58, 47 kDa
      Observed band size: 58 kDa
    • IHC image of CSB-PA823460LA01HU diluted at 1:700 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) GPT2 Polyclonal antibody
  • Uniprot No.：
    Q8TD30
  • 基因名：
    GPT2
  • 别名：
    AAT2 antibody; Alanine aminotransferase 2 antibody; ALAT2_HUMAN antibody; ALT2 antibody; Glutamate pyruvate transaminase 2 antibody; Glutamic alanine transaminase 2 antibody; Glutamic pyruvate transaminase (alanine aminotransferase) 2 antibody; Glutamic pyruvic transaminase 2 antibody; Glutamic--alanine transaminase 2 antibody; Glutamic--pyruvic transaminase 2 antibody; GPT 2 antibody; gpt2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Alanine aminotransferase 2 protein (95-208AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，GPT2 Antibody (CSB-PA823460LA01HU)，的标记方式是Non-conjugated。对于GPT2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA823460LB01HU GPT2 Antibody, HRP conjugated ELISA
    FITC CSB-PA823460LC01HU GPT2 Antibody, FITC conjugated
    Biotin CSB-PA823460LD01HU GPT2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:500-1:1000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate.
  • 基因功能参考文献：
    1. The GPT2 gene demonstrates increasing expression in brain in the early postnatal period, and GPT2 protein localizes to mitochondria. Akin to the human phenotype, Gpt2-null mice exhibit reduced brain growth. Through metabolomics and direct isotope tracing experiments, we find a number of metabolic abnormalities associated with loss of Gpt2 PMID: 27601654
    2. Recessively inherited loss of function GPT2 mutations are a novel cause of intellectual disability. PMID: 25758935
    3. ATF4 silencing prevented the activating effect of histidinol and tunicamycin on ATF4 and ALT2 expression. Our findings point to ALT2 as an enzyme involved in the metabolic adaptation of the cell to stress PMID: 24418603
    4. expression of GPT2 especially in muscle and fat, suggests a unique and previously unrecognized role of this gene product in glucose, amino acid, and fatty acid metabolism and homeostasis. PMID: 11863375
    5. The biliary IL-6 and TNF-alpha levels were positively correlated with serum DBIL, TBA and gamma-GT levels in infantile hepatitis syndrome subjects. PMID: 17109502
    6. Elevation of liver enzymes and hepatic insulin resistance as reflected by fasting insulin occur in the early stages of insulin resistance and highlight the central role of the liver in insulin resistance in the general population. PMID: 17596883
    7. A clinical method for selective measurement of ALT1 and 2 in human plasma is described. PMID: 19360321

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  • 相关疾病：
    Mental retardation, autosomal recessive 49 (MRT49)
  • 蛋白家族：
    Class-I pyridoxal-phosphate-dependent aminotransferase family, Alanine aminotransferase subfamily
  • 组织特异性：
    Expressed at high levels in muscle, adipose tissue, kidney and brain and at lower levels in the liver and breast.
  • 数据库链接：

    HGNC: 18062

    OMIM: 138210

    KEGG: hsa:84706

    STRING: 9606.ENSP00000345282

    UniGene: Hs.460693