GPX2 Antibody

1. GPx2 may play an important role in the development of nasopharyngeal carcinoma. Furthermore, GPx2 may serve as a prognostic biomarker for NPC patient. PMID: 28453466
2. Yes associated protein 1 (YAP) activation led to excessive accumulation of reactive oxygen species (ROS) by downregulating the antioxidant enzyme glutathione peroxidase GPX2 in a manner related to tumor protein p63 blockade. PMID: 28916653
3. Results showed that the expression of GPX2 was significantly up-regulated within esophageal squamous cell carcinoma tissues. PMID: 27388201
4. Glutathione peroxidase 2 expression is a novel independent prognostic biomarker for gastric carcinoma that may be used to devise personalized therapeutic regimens and precision treatments for this disease PMID: 28631563
5. glutathione peroxidase 2 overexpression contributes to poor prognosis of hepatocellular carcinoma patients and helps to identify the high-risk hepatocellular carcinoma patients. PMID: 28635398
6. Cardamonin exposure and selenium availability regulate expression of HO-1, GPX2 and TrxR1 in human intestinal cells. PMID: 26698667
7. GPX2 underexpression is associated with advanced tumor status and implicated unfavorable clinical outcome of UCs, suggesting its role in tumor progression and may serve as a theranostic biomarker of UCs. PMID: 25813210
8. high GPx2 expression was associated with early tumor recurrence, particularly in the recently identified aggressive subtype of human colon cancer. PMID: 25261240
9. Patients with high GPX2 expression in biopsy specimen had significantly lower prostate-specific antigen recurrence-free survival and overall survival than those with no GPX2 expression. PMID: 24562575
10. miR-185 plays a role in up-regulation of GPX2 and SEPHS2 expression. PMID: 23934683
11. A role of GPx2, TrxR2 and TrxR3 in proliferation, apoptosis and, therefore, also during cancer development. PMID: 22683372
12. A GPx2-independent decrease in tumor development by selenium (Se) and detrimental effects of the Nrf2-activator sulforaphane in moderate Se deficiency. PMID: 22758632
13. Cellular and subcellular localization of gastrointestinal glutathione peroxidase in normal and malignant human intestinal tissue PMID: 11811519
14. Data suggest that some antioxidants may exert their anti-inflammatory and anticarcinogenic effects not only by induction of phase 2 enzymes but also by the up-regulation of the selenoprotein GI-GPx by Nrf2 binding. PMID: 15923610
15. some isoforms of p63 serve as a pro-survival factor by up-regulating GPX2 to reduce the p53-dependent oxidative stress-induced apoptotic response PMID: 16446369
16. Glutathione peroxidase 2 (GPX2) is the major oxidative stress-inducible cellular GPX isoform in the lungs, and its basal as well as inducible expression is dependent on Nrf2. PMID: 16794261
17. SNPs involving the GSTP1, MnSOD and GPX2 genes were not associated with Barrett's esophagus or esophageal adenocarcinoma PMID: 17277236
18. Activation of the glutathione peroxidase 2 (GPx2) promoter by beta-catenin. PMID: 17937616
19. Gpx2 is an overexpressed gene in human breast cancers PMID: 18056462
20. Results show that GPx2 by compartmentalized removal of hydroperoxides silences COX-2 activity and suppresses PGE(2)-dependent COX-2 and mPGES-1 expression. PMID: 18479189
21. No significant risk for GPX2 in colorectal adenoma. PMID: 18483336
22. Data show that GPx2 inhibits malignant characteristics of tumor cells, migration and invasion, obviously by counteracting COX-2 expression but is required for the growth of transformed intestinal cells and may, therefore, facilitate tumor cell growth. PMID: 19047153
23. Knockout studies in mice suggest that Gpx2 mRNA and GPX-2 activity levels are induced by luminal microflora, consistent with a role in suppression of inflammation in the mucosal epithelium during weaning. PMID: 12751789

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HGNC: 4554

OMIM: 138319

KEGG: hsa:2877

STRING: 9606.ENSP00000374265

UniGene: Hs.2704