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GPX7 Antibody

  • 货号：
    CSB-PA009872GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q96SL4
  • 基因名：
  • 别名：
    CL683 antibody; FLJ14777 antibody; Glutathione peroxidase 7 antibody; GPx-7 antibody; GPX6 antibody; GPX7 antibody; GPX7_HUMAN antibody; GSHPx-7 antibody; NPGPx antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Human GPX7
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    It protects esophageal epithelia from hydrogen peroxide-induced oxidative stress. It suppresses acidic bile acid-induced reactive oxigen species (ROS) and protects against oxidative DNA damage and double-strand breaks.
  • 基因功能参考文献：
    1. SNPs most associated with Chemotherapy-induced peripheral neuropathy were in ATP-binding cassette sub-family C member 4 (ABCC4) gene. PMID: 25586538
    2. Loss of glutathione peroxidase 7 promotes TNF-alpha-induced NF-kappaB activation in Barrett's carcinogenesis. PMID: 24692067
    3. GPx7 promotes oxidative protein folding, directly utilizing Ero1alpha-generated hydrogen peroxide in the early secretory compartment. PMID: 23919619
    4. tumour suppressor functions in esophageal adenocarcinomas and silenced by location-specific promoter DNA methylation PMID: 23580780
    5. NPGPx protects against fat accumulation in mice and human via modulating ROS PMID: 23828861
    6. GPx7 is an unusual CysGPx catalyzing the peroxidatic cycle by a one Cys mechanism in which GSH and PDI are alternative substrates. PMID: 23454490
    7. NPGPx is essential for releasing excessive ER stress by enhancing GRP78 chaperone activity to maintain physiological homeostasis. PMID: 23123197
    8. GPx7 labeled as secreted glutathione peroxidase, is actually endoplasmic reticulum-resident protein disulfide isomerase peroxidase PMID: 21215271
    9. NPGPx plays an essential role in breast cancer cells in alleviating oxidative stress generated from polyunsaturated fatty acid metabolism PMID: 15294905

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  • 相关疾病：
    Barrett esophagus (BE)
  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Glutathione peroxidase family
  • 组织特异性：
    Expressed in esophageal epithelial cells; expression is up-regulated after exposure to acidic bile acids.
  • 数据库链接：

    HGNC: 4559

    OMIM: 614266

    KEGG: hsa:2882

    STRING: 9606.ENSP00000354677

    UniGene: Hs.43728