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  4. GREB1 Antibody

GREB1 Antibody

  • 货号：
    CSB-PA233008
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA233008(GREB1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA233008(GREB1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q4ZG55
  • 基因名：
    GREB1
  • 别名：
    5730583K22Rik antibody; 9130004E13 antibody; AF180470 antibody; AU023194 antibody; Gene regulated by estrogen in breast cancer protein antibody; Gene regulated in breast cancer 1 protein antibody; GREB 1 antibody; Greb1 antibody; GREB1_HUMAN antibody; KIAA0575 antibody; mKIAA0575 antibody; OTTHUMP00000180581 antibody; Protein GREB1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthetic peptide of Human GREB1
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May play a role in estrogen-stimulated cell proliferation. Acts as a regulator of hormone-dependent cancer growth in breast and prostate cancers.
  • 基因功能参考文献：
    1. GREB1 is a novel progesterone-responsive gene required for endometrial stromal decidualization. PMID: 28911214
    2. The aim of this study was to determine if genetic variation within GREB1 was associated with BMD variation. PMID: 28293781
    3. Whole exome sequence analysis of two families with renal agenesis identified a single candidate gene, GREB1L. Data implicates GREB1L as a coactivator for RARs. PMID: 28739660
    4. Which were rescued by wild-type human GREB1L mRNA. PMID: 29100090
    5. A significant association between GREB1L variants and BKA. PMID: 29100091
    6. the GREB1 region on chromosome 2p25.1 and the GREB1 gene may play a role in endometriosis risk PMID: 25788566
    7. GREB1 is a critical mediator of both the estrogen-stimulated proliferation of breast cancer cells and the androgen-stimulated proliferation of prostate cancer cells PMID: 24998469
    8. The expression of Greb1 was up-regulated in mouse tumors treated with E2 and was overexpressed in human ovarian cancers relative to human ovarian surface epithelium, suggesting a role for GREB1 in human ovarian tumor progression. PMID: 24469735
    9. RAD54B and GREB1 gene polymorphisms may not be associated with PCOS in the Han Chinese population. PMID: 23876972
    10. GREB1 is one of the central estrogen-specific ER cofactors, where it functions to mediate interactions between the ER and additional proteins. PMID: 23403292
    11. GREB1 alpha mRNA/protein expression levels were increased in ectopic tissue in peritoneal endometriosis. PMID: 22884659
    12. in ER-positive breast cancer cells, LRH-1 promotes cell proliferation by enhancing ERalpha mediated transcription of target genes such as GREB-1 PMID: 22359603
    13. Tissue expression of GREB1 is associated with organ-confined prostate cancer and may constitute a gene associated with a favorable prognosis. PMID: 19945309
    14. Longer survival was associated with hypomethylation at specific CpG sites (e.g. GREB1, TGIF and TOB1) and hypermethylation in other genes (e.g. TMCO5, PTPRN and GUCY2C). PMID: 21577013
    15. Characterize a monoclonal antibody that recognizes GREB1 protein in breast cancer cells. PMID: 19842031
    16. GREB1 is critically involved in the estrogen induced growth of breast cancer cells. PMID: 15986123
    17. GREB1 is expressed in proliferating prostatic tissue and prostate cancer, is regulated by androgens, and suppression of GREB1 blocks androgen-induced growth suggesting GREB1 may be critically involved in prostate cancer proliferation. PMID: 16496412
    18. Data show that the induction of the gene regulated in breast cancer 1 (GREB1) is mediated by binding of estrogen receptor alpha to three consensus estrogen response elements spread over approximately 20 kb of upstream flanking sequences. PMID: 17463000
    19. estrogen-stimulated GREB1 transcription may involve coordinated ER binding to all three distal consensus ERE motifs PMID: 17666587
    20. GREB1 is expressed in human skin, and is dose-dependently induced by topical 17-beta-estradiol treatment PMID: 18794456
    21. Estrogen receptors are recruited at several proximal and distal estrogen response elements upstream of the GREB1 transcription unit. PMID: 15001666

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  • 亚细胞定位：
    Membrane; Single-pass membrane protein.
  • 蛋白家族：
    GREB1 family
  • 组织特异性：
    Expressed in proliferating prostatic tissue and prostate cancer.
  • 数据库链接：

    HGNC: 24885

    OMIM: 611736

    KEGG: hsa:9687

    STRING: 9606.ENSP00000234142

    UniGene: Hs.467733