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GRIK1 Antibody

  • 货号：
    CSB-PA008963
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    P39086
  • 基因名：
  • 别名：
    EAA3 antibody; EEA3 antibody; Excitatory amino acid receptor 3 antibody; GLR5 antibody; GluR-5 antibody; GluR5 antibody; GluR6 antibody; GluR7 antibody; Glutamate receptor 5 antibody; Glutamate receptor antibody; Glutamate receptor ionotropic kainate 1 antibody; GRIK1 antibody; GRIK1_HUMAN antibody; Human glutamate receptor GLUR5 antibody; ionotropic kainate 1 antibody; OTTHUMP00000096569 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the N-terminal region of Human GluR-5.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus.
  • 基因功能参考文献：
    1. DRD2 A2/A1, DRD3 Ser9Gly, DbetaH -1021C>T, OPRM1 A118G and GRIK1 rs2832407C>A are not associated with alcoholism alone or in interaction. PMID: 27447243
    2. The findings reported here suggest that, in participants with the GRIK1 rs2832407*CC genotype, topiramate treatment enhances self-efficacy and reduces heavy drinking. PMID: 25496338
    3. Findings indicate that SNPs in the GRIK1 gene is associated with altered cue-induced brain activation that is related to craving for alcohol and relapse risk. PMID: 26289945
    4. Results suggested that the extracellular N-terminal region including the two CUB domains was largely responsible for the distinct regulatory effects of Neto1 and Neto2 on the desensitization properties of GluK1 homomeric receptors PMID: 26277340
    5. In the present study, we have shown that gene-gene interaction of components of different systems associated with nicotine reinforcing effects, such as OPRM1 and GRIK1, rather than one gene polymorphism, is associated with smoking behavior. PMID: 25941919
    6. This found that, among rs2832407*C of GRIK1 homozygotes, topiramate treatment produced the greatest reductions in the expected positive effects of drinking and desire to drink during the treatment period. PMID: 24786948
    7. These results suggest that the effect of topiramate on drinking behavior, in which the GluK1-containing kainate receptor appears to play a key role, can be dissociated from its effect on weight. PMID: 24978347
    8. Topiramate treatment for alcohol dependence was significantly more effective in rs2832407 C-allele homozygotes. PMID: 24525690
    9. Reduced Homer binding to mGluR5 supports an inhibitory role for Homer interactions with mGluR5 in mediating neuropathy. PMID: 23685007
    10. Using the SNaPshot assay, we present evidence for allelic nondisjunction at rs363506 in the GRIK1 gene and rs2834235 and rs7283354 in the GARS-AIRS-GART gene in Down syndrome in India. PMID: 22931243
    11. The association at rs455804 implicates GRIK1 as a novel susceptibility gene for HBV-related HCC, suggesting the involvement of glutamate signaling in the development of HBV-related HCC. PMID: 22807686
    12. GRIK1 rs469472 to be possibly associated with schizophrenia in our independent case-control and family samples PMID: 22730074
    13. Presynaptic Gluk1 kainate receptors that reduce transmitter release downstream are independent of divalent calcium ion Ca2+ influx. PMID: 20848601
    14. The amino acid sequence of the GluK1 kainate receptor near or within the carboxyl-terminal endoplasmic reticulum retention signal sequence, which affects receptor trafficking and/or expression, does not affect channel gating properties. PMID: 22191429
    15. The GRIK1 promoter is activated by Trichostatin A (TSA) treatment and by serum depletion according to promoter reporter assays in HEK 293 cells. PMID: 20494980
    16. findings show GluR5 was upregulated in the hippocampus, but not in the temporal neocortex, of patients with temporal lobe epilepsy (TLE)compared to controls; mossy fiber sprouting in the hippocampus of TLE patients was correlated with GluR5 upregulation PMID: 19941835
    17. Variation in the 3' portion of the gene encoding the GluR5 kainate receptor subunit contributes to the risk for alcohol dependence. PMID: 19320626
    18. GluK1 kainate receptor polymorphisms are associated with Down syndrome. PMID: 19893199
    19. GRIK1 does not play a major role in schizophrenia pathogenesis in the Japanese population PMID: 11702055
    20. there are trafficking signals in the C-terminal domain of GluR5-2b; alternative splicing is an important mechanism regulating KAR function PMID: 14527949
    21. Two amino acids,competitive GluR5 KA receptor antagonists, exhibited high GluR5 receptor affinity over other glutamate receptors. PMID: 15974569
    22. This kainate receptor subunit appears to be selectively altered in the anterior cingulate cortex in schizophrenia and bipolar disorder. PMID: 17698324

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Glutamate-gated ion channel (TC 1.A.10.1) family, GRIK1 subfamily
  • 组织特异性：
    Most abundant in the cerebellum and the suprachiasmatic nuclei (SCN) of the hypothalamus.
  • 数据库链接：

    HGNC: 4579

    OMIM: 138245

    KEGG: hsa:2897

    STRING: 9606.ENSP00000382791

    UniGene: Hs.664641