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GRIK3 Antibody

  • 货号：
    CSB-PA623779ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA623779ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA623779ESR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) GRIK3 Polyclonal antibody
  • Uniprot No.：
    Q13003
  • 基因名：
  • 别名：
    EAA5 antibody; Excitatory amino acid receptor 5 antibody; GLR 7 antibody; GLR7 antibody; GLU R7 antibody; GLUR 7 antibody; GluR 7a antibody; GluR-7 antibody; GluR7 antibody; GluR7a antibody; Glutamate receptor 7 antibody; Glutamate receptor antibody; Glutamate receptor ionotropic kainate 3 antibody; GRIK 3 antibody; GRIK3 antibody; GRIK3_HUMAN antibody; ionotropic kainate 3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Glutamate receptor ionotropic, kainate 3 protein (32-240AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate > kainate >> L-glutamate = quisqualate >> AMPA = NMDA.
  • 基因功能参考文献：
    1. additional experiment showed that the lymph node metastasis tissues had higher GRIK3 expression than their matched primary gastric cancer (GC) tissues. These findings suggested that elevated GRIK3 expression could serve as an independent prognostic biomarker and a novel potential treatment target for patients with GC. PMID: 28631555
    2. GRIK3 expression is significantly downregulated in human masticatory mucosa during wound healing PMID: 28005267
    3. 1p34.3 deletion involving GRIK3: Further clinical implication of GRIK family glutamate receptors in the pathogenesis of developmental delay. PMID: 24449200
    4. Analyses revealed that polymorphism Ser310Ala of GRIK3 gene is not associated with alcohol dependence or any of its subgroups. PMID: 23006490
    5. Our results suggest that the analysed polymorphisms ofANKK1 and ADH4 can play an important part in the pathogenesis of alcohol abuse PMID: 22232963
    6. Some support (at a nominal significance level of 0.05/0.01) was found for association between GRIK3 and depression. PMID: 20052609
    7. Our study suggests a potential role for GRIK3 for susceptibility to schizophrenia in Indian population. PMID: 19921975
    8. Association between the ionotropic glutamate receptor kainate 3 (GRIK3) ser310ala polymorphism and schizophrenia. PMID: 11986986
    9. suggestive for a significant role of GRIK3 polymorphism in the pathogenesis of delirium tremens in alcohol-dependent individuals PMID: 16314883
    10. These findings do not seem to support the hypothesis of the role of this polymorphism in the pathogenesis of alcoholism. PMID: 16356644
    11. significant linkage disequilibrium (LD) indicated by preferential maternal transmission of the GluR7 S310 allele to recurrent major depressive disorder patients (P = 0.012), but not to bipolar I disorder (BPI) patients (P = 1.00) PMID: 16958029
    12. The present results, although not robust, support the importance of more extensive investigations of GRIK3, given its potential role in mediating risk for schizophrenia. PMID: 19022628
    13. functional GRIK3 Ser310Ala polymorphism is homozygosity is associated with higher scores in harm avoidance and respective subscales of personality traits PMID: 19221446

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Glutamate-gated ion channel (TC 1.A.10.1) family, GRIK3 subfamily
  • 数据库链接：

    HGNC: 4581

    OMIM: 138243

    KEGG: hsa:2899

    STRING: 9606.ENSP00000362183

    UniGene: Hs.128848