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GRPEL1 Antibody

  • 货号：
    CSB-PA875707ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: GRPEL1 antibody at 2.65µg/ml
      Lane 1: A431 whole cell lysate
      Lane 2: 293T whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 24 kDa
      Observed band size: 24, 26 kDa
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA875707ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA875707ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) GRPEL1 Polyclonal antibody
  • Uniprot No.：
    Q9HAV7
  • 基因名：
  • 别名：
    FLJ25609 antibody; GREPEL 1 antibody; GREPEL1 antibody; GrpE like 1 antibody; GrpE like 1 mitochondrial antibody; GrpE like protein cochaperone antibody; GrpE protein homolog 1 mitochondrial antibody; GrpE protein homolog 1; mitochondrial antibody; GRPE1_HUMAN antibody; GRPEL 1 antibody; Grpel1 antibody; HMGE antibody; Mt GrpE#1 antibody; Mt-GrpE#1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human GrpE protein homolog 1, mitochondrial protein (1-217AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins.
  • 基因功能参考文献：
    1. Data suggest that two putative NEF (nucleotide exchange factors) orthologs, GRPEL1 and GRPEL2, modulate function of mitochondrial HSP70 (mtHSP70); both GRPEL1 and GRPEL2 associate with mtHSP70 as hetero-oligomeric subcomplex and regulate mtHSP70 transport. (GRPEL = mitochondrial GrpE-like protein; HSP70 = heat-shock protein 70) PMID: 28848044
    2. The low resolution structure of human GrpE presented suggests that GrpE is a symmetric dimer when not bound to DnaK PMID: 12840016
  • 亚细胞定位：
    Mitochondrion matrix.
  • 蛋白家族：
    GrpE family
  • 数据库链接：

    HGNC: 19696

    OMIM: 606173

    KEGG: hsa:80273

    STRING: 9606.ENSP00000264954

    UniGene: Hs.443723