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GTF2E2 Antibody

  • 货号：
    CSB-PA004267
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of Jurkat cells using TFIIE-β Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    P29084
  • 基因名：
    GTF2E2
  • 别名：
    FE antibody; General transcription factor IIE subunit 2 antibody; General transcription factor IIE; polypeptide 2; beta 34kDa antibody; gtf2e2 antibody; T2EB_HUMAN antibody; TF2E 2 antibody; TF2E2 antibody; TFIIE B antibody; TFIIE-beta antibody; Transcription initiation factor IIE beta subunit antibody; Transcription initiation factor IIE subunit beta antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human TFIIE-β.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.
  • 基因功能参考文献：
    1. functional analysis of Trichothiodystrophy causative TFIIEbeta mutation demonstrates that mutant TFIIEbeta strongly reduces the total amount of the entire TFIIE complex, with a remarkable temperature-sensitive transcription defect. PMID: 28973399
    2. We underline role of TFIIE in transcription and its distinction from nucleotide excision repair. Trichothiodystrophy individuals with mutations in GTF2E2 highlight the importance of the direct interaction between TFIIH and TFIIE in transcription process. PMID: 26996949
    3. PC4 plays essential roles in the transition step from transcription initiation to elongation by binding to melted DNA in collaboration with TFIIEbeta. PMID: 25308091
    4. introduced point mutations into two regions located near the carboxy terminus of TFIIE beta and identified the functionally essential amino acid residues that bind to RNA polymerase II PMID: 12665589
    5. TFIIE is an alpha/beta heterodimer in solution; A model for the quaternary architecture of the complex is proposed that provides a structural framework to discuss the function of TFIIE in the context of RNA polymerase II transcription initiation. PMID: 16547462
    6. These data suggest a model in which TFIIE binds to a position adjacent to the initiation site via the forkhead domain, enabling TFIIH to begin opening the promoter. PMID: 19210545

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  • 相关疾病：
    Trichothiodystrophy 6, non-photosensitive (TTD6)
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    TFIIE beta subunit family
  • 数据库链接：

    HGNC: 4651

    OMIM: 189964

    KEGG: hsa:2961

    STRING: 9606.ENSP00000348168

    UniGene: Hs.77100