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GUCA2B Antibody

  • 货号：
    CSB-PA613693GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) GUCA2B Polyclonal antibody
  • Uniprot No.：
    Q16661
  • 基因名：
    GUCA2B
  • 别名：
    GUCA2B antibody; GCAP II antibody; GCAP-II antibody; Guanylate cyclase activator 2B (uroguanylin) antibody; Guanylate cyclase activator 2B antibody; Guanylate cyclase C-activating peptide II antibody; GUC2B_HUMAN antibody; GUCA2B antibody; UGN antibody; Uroguanylin antibody
  • 宿主：
    Rabbit
  • 反应种属：
    human,Mouse,Rat
  • 免疫原：
    Human uroguanylin
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport.
  • 基因功能参考文献：
    1. The simulations suggested that all missense SNPs considered as convergent deleterious caused some kind of structural change to the uroguanylin peptide. Additionally, four of these SNPs were also shown to cause modifications in peptide flexibility, possibly resulting in functional changes. PMID: 27620667
    2. Uroguanylin concentrations are increased in patients with chronic renal failure, nephrotic syndrome, or those on dialysis. PMID: 15780094
    3. The occurrences of the C-A haplotype (rs883062-rs1047047) and the C-A-G haplotype (rs883062-rs1047047-rs2297566) were significantly higher in the essential hypertension group than in the controls. PMID: 18037771
  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Guanylin family
  • 组织特异性：
    Stomach and intestine.
  • 数据库链接：

    HGNC: 4683

    OMIM: 601271

    KEGG: hsa:2981

    STRING: 9606.ENSP00000361662

    UniGene: Hs.32966