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GUCY1B3 Antibody

  • 货号：
    CSB-PA010052GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q02153
  • 基因名：
  • 别名：
    GC-S-beta-1 antibody; GC-SB3 antibody; GCbeta1 antibody; GCS beta 1 antibody; GCS beta 3 antibody; GCS-beta-1 antibody; GCS-beta-3 antibody; GCYB1_HUMAN antibody; guanylate cyclase 1; soluble; beta 3 antibody; Guanylate cyclase soluble beta 1 chain antibody; Guanylate cyclase soluble subunit beta-1 antibody; Guanylate cyclase soluble subunit beta-3 antibody; GUC1B3 antibody; GUCSB3 antibody; GUCY1B1 antibody; Gucy1b1; antibody; GUCY1B3 antibody; SGC antibody; Soluble guanylate cyclase small subunit antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human GUCY1B3
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IF
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Mediates responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP.
  • 基因功能参考文献：
    1. Our observations revealed that rs7638A/C polymorphism of GUCY1B3 and the longer telomere length inclined toward adaptation to high altitude. PMID: 29443612
    2. Inhibition of HDAC3 with targeted therapy could benefit treatment of the diseases associated with sGCbeta1 down-regulation and/or deficiency such as cancer and several vascular-related diseases. PMID: 27279362
    3. The kinetics of heme loss from oxidized sGC was monitored by a new method based on the heme group de-quenching the fluorescence of FlAsH-EDT2. PMID: 26876536
    4. Gene expression in dendritic cells of CCL5 and CXCL5 as well as TIMP1 and GUCY1B3 showed a significant increase within the first 4 days after trauma. PMID: 23179318
    5. The results indicate that in comparison with the alpha-1 beta-1 isoform, the brain alpha-2 beta-1 isoform exhibits a distinctly different CO/NO affinity and binding rate in favor of NO signaling. PMID: 22426988
    6. Data show that show that it is possible to directly monitor the sGC haem oxidation state in intact cells. By inserting the TC motif into the coding sequence of the beta1 subunit of sGC in transiently transfected Chinese hamster ovary cells. PMID: 21858179
    7. recombinant soluble guanylate cyclase (sGC) beta1 subunit and truncated N-terminal fragments expressed in E. coli; studied interaction between NO and sGC and schematic mechanism was proposed; study provides insights into structure and NO-binding of sGC PMID: 20063108
    8. Results show that NOGCbeta1 and GC-A interact and that NOGCbeta1 regulates atrial natriuretic peptide signaling in HK-2 cells. PMID: 20024606
    9. The mutant analysis indicated an importance for not only certain dimerization residue positions, but also an important role for other faces of the coiled coil dimer which might perhaps interact with adjacent domains PMID: 20105301
    10. Although soluble guanylate cyclase(sGC) beta1-subunit expression was increased in mononuclear cells from patients with erectile dysfunction, the sGC activity was reduced PMID: 16528291

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Adenylyl cyclase class-4/guanylyl cyclase family
  • 组织特异性：
    Detected in brain cortex and cerebellum (at protein level).
  • 数据库链接：

    HGNC: 4687

    OMIM: 139397

    KEGG: hsa:2983

    STRING: 9606.ENSP00000264424

    UniGene: Hs.77890