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GZMK Antibody

  • 货号：
    CSB-PA010084LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA010084LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human spleen tissue using CSB-PA010084LA01HU at dilution of 1:100
    • Immunofluorescent analysis of HepG2 cells using CSB-PA010084LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) GZMK Polyclonal antibody
  • Uniprot No.：
    P49863
  • 基因名：
    GZMK
  • 别名：
    Fragmentin 3 antibody; Fragmentin-3 antibody; Fragmentin3 antibody; GRAK_HUMAN antibody; Granzyme 3 antibody; granzyme K (granzyme 3; tryptase II) antibody; granzyme K (serine protease; granzyme 3; tryptase II) antibody; Granzyme K antibody; Granzyme K precursor antibody; Granzyme-3 antibody; Granzyme3 antibody; GranzymeK antibody; GZMK antibody; NK TRYP 2 antibody; NK TRYP2 antibody; NK tryptase 2 antibody; NK-TRYP-2 antibody; NK-tryptase-2 antibody; NKTRYP2 antibody; Serine protease granzyme 3 antibody; TRYP 2 antibody; TRYP2 antibody; Tryptase II antibody; TryptaseII antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Granzyme K protein (27-264AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，GZMK Antibody (CSB-PA010084LA01HU)，的标记方式是Non-conjugated。对于GZMK Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA010084LB01HU GZMK Antibody, HRP conjugated ELISA
    FITC CSB-PA010084LC01HU GZMK Antibody, FITC conjugated
    Biotin CSB-PA010084LD01HU GZMK Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 基因功能参考文献：
    1. Extracellular granzyme K mediates endothelial activation through the cleavage of PAR-1. PMID: 26936634
    2. Extracellular GrK is an unexpected direct modulator of lipopolysaccharide-TLR4 signaling during the antimicrobial innate immune response. PMID: 24711407
    3. Granzyme K plays an important physiological role in immunoregulation of adaptive immunity underlying the cytotoxicity of CD56(bright) natural killer (NK) cells toward activated T cells. PMID: 21666061
    4. Gr3 proenzymes is activated by cathepsin C which concomitantly decreased the molecular weight to that of active Gr3. PMID: 20377743
    5. The 2.2-A crystal structure reveals a rigid zymogen with unusual features PMID: 12384499
    6. The present findings thus introduce the possibility that human beta-tryptase, after mast cell degranulation and exposure to neutral pH in the tissue, may dissociate into active monomers with properties that are distinct from the tetrameric counterpart. PMID: 12387726
    7. We found human GzmK triggers rapid cell death independently of caspase activation. The features of death are characterized by rapid externalization of phosphatidylserine, nuclear morphological changes and single-stranded DNA nicks. PMID: 17008916
    8. Rsults indicate that plasma levels of Granzyme K could serve as a useful diagnostic marker to stage sepsis, permitting better classification, specific treatments of patients, and may play a functional role in the development of sepsis. PMID: 17438453
    9. p53 is as a cytotoxic bomb that can be triggered by granzyme K, leading to potentiating killing efficacy. PMID: 19201868

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  • 亚细胞定位：
    Secreted. Cytoplasmic granule.
  • 蛋白家族：
    Peptidase S1 family, Granzyme subfamily
  • 组织特异性：
    Expressed in lung, spleen, thymus and peripheral blood leukocytes.
  • 数据库链接：

    HGNC: 4711

    OMIM: 600784

    KEGG: hsa:3003

    STRING: 9606.ENSP00000231009

    UniGene: Hs.277937