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Gp2 Antibody

  • 货号：
    CSB-PA880511LA01MO
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Mus musculus (Mouse) Gp2 Polyclonal antibody
  • Uniprot No.：
    Q9D733
  • 基因名：
    Gp2
  • 别名：
    Gp2 antibody; Pancreatic secretory granule membrane major glycoprotein GP2 antibody; Pancreatic zymogen granule membrane protein GP-2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Mouse
  • 免疫原：
    Recombinant Mouse Pancreatic secretory granule membrane major glycoprotein GP2 protein (22-531AA)
  • 免疫原种属：
    Mus musculus (Mouse)
  • 标记方式：
    Non-conjugated

    本页面中的产品，Gp2 Antibody (CSB-PA880511LA01MO)，的标记方式是Non-conjugated。对于Gp2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA880511LB01MO Gp2 Antibody, HRP conjugated ELISA
    FITC CSB-PA880511LC01MO Gp2 Antibody, FITC conjugated
    Biotin CSB-PA880511LD01MO Gp2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Functions as an intestinal M-cells transcytotic receptor specific of type-I-piliated bacteria that participate in the mucosal immune response toward these bacteria. At the apical membrane of M-cells binds fimH, a protein of the bacteria type I pilus tip. Internalizes bound bacteria, like E.coli and S.typhimurium, from the lumen of the intestine and delivers them, through M-cells, to the underlying organized lymphoid follicles where they are captured by antigen-presenting dendritic cells to ellicit a mucosal immune response.
  • 基因功能参考文献：
    1. GP2 is a popular secretory product released from mucous glands and secretory cells and may support defense mechanisms against pathogenic bacteria in the tubular organs open to the external milieu. PMID: 28003582
    2. GP2-expressing cells in paranasal sinuses are in the lineage of goblet cells. PMID: 25355440
    3. Tightly linked to homologue THP. A Gp2 knockout mouse was established which does express THP. PMID: 15325280
    4. unlikely that GP2 serves a major intracellular role within the acinar cell, may be active after it is secreted PMID: 15385539
    5. glycoprotein 2 (GP2), specifically expressed on the apical plasma membrane of M cells among enterocytes, serves as a transcytotic receptor for mucosal antigens PMID: 19907495

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  • 亚细胞定位：
    Zymogen granule membrane; Lipid-anchor, GPI-anchor. Secreted. Cell membrane; Lipid-anchor, GPI-anchor. Apical cell membrane; Lipid-anchor, GPI-anchor. Membrane raft; Lipid-anchor, GPI-anchor. Endosome.
  • 组织特异性：
    Specifically expressed by M (microfold) cells which are atypical epithelial cells of the intestine.
  • 数据库链接：

    KEGG: mmu:67133

    STRING: 10090.ENSMUSP00000033255

    UniGene: Mm.46403