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Guca2b Antibody

  • 货号：
    CSB-PA010048LA01MO
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Mus musculus (Mouse) Guca2b Polyclonal antibody
  • Uniprot No.：
    O09051
  • 基因名：
    Guca2b
  • 别名：
    Guca2b antibody; Guanylate cyclase activator 2B [Cleaved into: Uroguanylin antibody; UGN)] antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Mouse
  • 免疫原：
    Recombinant Mouse Guanylate cyclase activator 2B protein (22-106AA)
  • 免疫原种属：
    Mus musculus (Mouse)
  • 标记方式：
    Non-conjugated

    本页面中的产品，Guca2b Antibody (CSB-PA010048LA01MO)，的标记方式是Non-conjugated。对于Guca2b Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA010048LB01MO Guca2b Antibody, HRP conjugated ELISA
    FITC CSB-PA010048LC01MO Guca2b Antibody, FITC conjugated
    Biotin CSB-PA010048LD01MO Guca2b Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport.
  • 基因功能参考文献：
    1. In obese mice UGN expression was decreased, whereas leptin treatment up-regulated UGN levels in duodenum in these genetically modified mice compared to WT. PMID: 25743370
    2. UGN exerts its inhibitory activity on the prendrin gene promoter likely via heat shock factor 1 action at a defined heat shock element site. PMID: 22129966
    3. findings establish a role for uroguanylin in an enteric-renal communication axis as well as a fundamental principle of this axis in the maintenance of salt homeostasis in vivo PMID: 14561709
    4. act on the mouse kidney, in part, through a cGMP-dependent, GC-C-independent mechanism, causing significant natriuresis by renal tubular processes. PMID: 14675035
    5. Role for uroguanylin in fluid homeostasis and as an integral component of a signaling mechanism that mediates changes in Na excretion in response to an enteral salt loading. PMID: 16819406

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Guanylin family
  • 组织特异性：
    Localized predominantly in intestinal villi and the corticomedullary junction of the kidney.
  • 数据库链接：

    KEGG: mmu:14916

    STRING: 10090.ENSMUSP00000043203

    UniGene: Mm.278