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HACE1 Antibody

  • 货号：
    CSB-PA223356
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA223356(HACE1 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using CSB-PA223356(HACE1 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q8IYU2
  • 基因名：
    HACE1
  • 别名：
    HACE1 antibody; KIAA1320E3 ubiquitin-protein ligase HACE1 antibody; EC 2.3.2.26 antibody; HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1 antibody; HECT-type E3 ubiquitin transferase HACE1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic peptide of Human HACE1
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:100-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. May also act as a transcription regulator via its interaction with RARB.
  • 基因功能参考文献：
    1. A functional interplay between HACE1 and Rac1 in cancer, is reported. PMID: 28317937
    2. Results identified HACE1 Ser-385 as a pivotal amino acid residue that is phosphorylated in response to CNF1 or VEGF treatments and that expression of activated Rac1 is sufficient to induce HACE1 phosphorylation and controlling its oligomerization state. PMID: 29362425
    3. Results indicated that HACE1 rs9404576 polymorphism may be associated with Wilms' tumor susceptibility in the Chinese population. PMID: 29243987
    4. 3-deazaneplanocin A treatment increased HACE1 gene expression which was further increased by the addition of trichostatine A (TSA), a promising therapeutic compound for the treatment of human B-Lymphoma PMID: 28651105
    5. HACE1 can act as a haploinsufficient tumor suppressor gene in most B-cell lymphomas and can be downregulated by deacetylation of its promoter region chromatin PMID: 27107267
    6. Hepatocellular carcinoma patients with low HACE1 expression levels exhibited poorer overall survival and HACE1 was found to be an independent prognostic factor for survival. PMID: 27805249
    7. HACE1 as a specific E3 ligase that polyubiquitinates YB-1 through non-canonical K27 linked ubiquitin chains. PMID: 26343856
    8. Biallelic loss-of-function mutations in HACE1 are associated with an autosomal recessive neurodevelopmental syndrome. PMID: 26424145
    9. supports a critical role for HACE1 in breast cancer progression and identifies patients that may benefit from Rac-targeted therapies PMID: 25659579
    10. contrary to previous report, overexpression of HACE1 by transduction of recombinant protein did not affect proliferation or survival of NKTCL cell lines. We therefore conclude that HACE1 is not directly involved in NKTCL pathophysiology PMID: 25203537
    11. HACE1-OPTN axis synergistically suppresses growth and tumorigenicity of lung cancer cells. PMID: 25026213
    12. Ubiquitylation and activation of RAB11a is promoted by a beta2 adrenergic receptor-HACE1 complex. PMID: 24190883
    13. HACE1 reduces oxidative stress and mutant Huntingtin toxicity by promoting the NRF2 response. PMID: 24516159
    14. All stages of HCCs presented HACE1 methylation, indicating that the HACE1 gene has been methylated from the early stages of HCCs. PMID: 23732777
    15. HACE1 is tumor suppressor gene located within the 6q21 region, and loss of function of multiple tumor suppressor genes within 6q21 may be a critical determinant of NK cell lymphomagenesis. PMID: 23142381
    16. HACE1 is an antagonist of cell migration through its ability to degrade active Rac1. PMID: 22614015
    17. common variants in HACE1 and LIN28B influence neuroblastoma susceptibility and indicate that both genes likely have a role in disease progression. PMID: 22941191
    18. The HACE1 expression increases the ubiquitylation of Rac1, when the GTPase is activated by point mutations or by the GEF-domain of Dbl. PMID: 22036506
    19. The 6q21-22 region was confirmed as a celiac disease susceptibility locus and harbors multiple independent associations, some of which may implicate ubiquitin-pathways in celiac disease susceptibility, such as mutations in gene HACE1. PMID: 21326284
    20. Deregulation of the tumor suppressor HACE1 is associated with natural killer/T-cell lymphoma, nasal type. PMID: 19965620
    21. Hace1 as a novel ubiquitin-protein ligase with very low expression Wilms' tumors; hypermethylation of two upstream CpG islands correlates with low HACE1 expression in tumor samples. PMID: 15254018
    22. HACE1 is a candidate chromosome 6q21 tumor-suppressor gene involved in multiple cancers. PMID: 17694067
    23. Aberrant methylation of the HACE1 gene was detected in 9 out of the 32 (28%) primary colon carcinomas. PMID: 18630515
    24. Aberrant methylation of the HACE1 gene is associated with gastric carcinoma. PMID: 19528486

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  • 相关疾病：
    Spastic paraplegia and psychomotor retardation with or without seizures (SPPRS)
  • 亚细胞定位：
    Golgi apparatus, Golgi stack membrane. Cytoplasm. Endoplasmic reticulum. Note=A significant portion localizes to the endoplasmic reticulum. Targeted to Golgi membrane via its interaction with Rab proteins.
  • 组织特异性：
    Expressed in multiple tissues including heart, brain and kidney.
  • 数据库链接：

    HGNC: 21033

    OMIM: 610876

    KEGG: hsa:57531

    STRING: 9606.ENSP00000262903

    UniGene: Hs.434340