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HAGH Antibody

  • 货号：
    CSB-PA11195A0Rb
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA11195A0Rb at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) HAGH Polyclonal antibody
  • Uniprot No.：
    Q16775
  • 基因名：
    HAGH
  • 别名：
    HAGH antibody; GLO2 antibody; HAGH1Hydroxyacylglutathione hydrolase antibody; mitochondrial antibody; EC 3.1.2.6 antibody; Glyoxalase II antibody; Glx II antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Hydroxyacylglutathione hydrolase, mitochondrial protein (50-308AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，HAGH Antibody (CSB-PA11195A0Rb)，的标记方式是Non-conjugated。对于HAGH Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA11195B0Rb HAGH Antibody, HRP conjugated ELISA
    FITC CSB-PA11195C0Rb HAGH Antibody, FITC conjugated
    Biotin CSB-PA11195D0Rb HAGH Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.
  • 基因功能参考文献：
    1. Down regulation of Glyoxalase II was observed in cases of diabetic retinopathy as compared to controls. PMID: 29950256
    2. The critical role of glyoxalases as regulators of tumorigenesis in the prostate through modulation of various critical signaling pathways, and an overview of the current knowledge on glyoxalases in bladder, kidney and testis cancers is reviewed. (GLO1, GLO2) PMID: 29385039
    3. epidermal expression stronger in older skin donors PMID: 26914966
    4. Glo2, together with Glo1, represents a novel mechanism in prostate cancer progression as part of a pathway driven by PTEN/PI3K/AKT/mTOR signaling. PMID: 27696457
    5. This article reports for the first time a possible additional role of Glo2 that, after interacting with a target protein, is able to promote S-glutathionylation. PMID: 27935136
    6. This study suggested that HAGH, rs11859266 and rs3743852 showed significant associations with schizophrenia in males at allelic and genotype levels. PMID: 25645869
    7. No association between genetic variants of the HAGH gene and autism spectrum disorder was found. PMID: 24671236
    8. hydroxyacylglutathione hydrolase (HAGH) gene encodes both cytosolic and mitochondrial forms of glyoxalase II PMID: 15117945
    9. Overexpression of glyoxalase II is associated with kidney tumor PMID: 16803681
    10. Data show that the GLX2 gene, which encodes glyoxalase II enzyme, is up-regulated by p63 and p73. PMID: 16831876
    11. In androgen-dependent prostate cancer cells, testosterone upregulates GLO2 mRNA levels. In androgen-independent prostate cancer cells, it downregulates GLO2 mRNA. PMID: 18344682
    12. Human glyoxalase II contains an Fe(II)Zn(II) center but is active as a mononuclear Zn(II) enzyme PMID: 19413286

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  • 亚细胞定位：
    [Isoform 1]: Mitochondrion matrix.; [Isoform 2]: Cytoplasm.
  • 蛋白家族：
    Metallo-beta-lactamase superfamily, Glyoxalase II family
  • 组织特异性：
    Expressed in liver and kidney.
  • 数据库链接：

    HGNC: 4805

    OMIM: 138760

    KEGG: hsa:3029

    STRING: 9606.ENSP00000380514

    UniGene: Hs.157394