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HAX1 Antibody

  • 货号：
    CSB-PA03515A0Rb
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Mouse brain tissue, Rat brain tissue
      All lanes: HAX1 antibody at 1.5µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 32, 33, 29, 15, 27, 22 kDa
      Observed band size: 32 kDa
    • IHC image of CSB-PA03515A0Rb diluted at 1:150 and staining in paraffin-embedded human gastric cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescent analysis of Hela cells using CSB-PA03515A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) HAX1 Polyclonal antibody
  • Uniprot No.：
    O00165
  • 基因名：
    HAX1
  • 别名：
    FLJ17042 antibody; FLJ18492 antibody; FLJ93803 antibody; HAX 1 antibody; HAX-1 antibody; HAX1 antibody; HAX1_HUMAN antibody; Hax1a antibody; HCLS1 and PKD2 associated protein antibody; HCLS1 associated protein antibody; HCLS1 associated protein X 1 antibody; HCLS1-associated protein X-1 antibody; HCLSBP1 antibody; HS 1 associated protein X 1 antibody; HS 1 binding protein antibody; HS1 associating protein X 1 antibody; HS1 binding protein 1 antibody; HS1 binding protein antibody; HS1-associating protein X-1 antibody; HS1-binding protein 1 antibody; HS1BP1 antibody; HSP1BP-1 antibody; OTTHUMP00000034190 antibody; SCN3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human HCLS1-associated protein X-1 protein (2-250AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，HAX1 Antibody (CSB-PA03515A0Rb)，的标记方式是Non-conjugated。对于HAX1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA03515B0Rb HAX1 Antibody, HRP conjugated ELISA
    FITC CSB-PA03515C0Rb HAX1 Antibody, FITC conjugated
    Biotin CSB-PA03515D0Rb HAX1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools.
  • 基因功能参考文献：
    1. data suggest that HAX-1 may be a promoting factor for AIV H9N2 replication through desensitizing PB1-F2 from its apoptotic induction in human lung epithelial cells. PMID: 29576744
    2. the HAX1 gene is important for ovarian development, in which a p.Trp44X mutation may cause primary ovarian insufficiency in female patients PMID: 28681255
    3. The overexpression of HAX-1 might contribute to the malignant progression of glioma. PMID: 28751207
    4. Autophagy induction is involved in HAX1-induced cell protective mechanism, and AA127-180 serves as the functional autophagy-regulatory domain of this antiapoptotic protein. PMID: 29461873
    5. HAX1 is a potential oncogene, and may promote the tumorigenesis and progression of hypopharyngeal carcinoma. PMID: 28791389
    6. Oncogenic HAX-1 increases the proliferation, migration, and angiogenic activity of HUVECs. Findings provide unique insight into the pathogenesis of NPC. PMID: 26871467
    7. Results show that Grb7 and Hax1 may colocalize partially to mitochondria in EGF-treated SKBR3 cells and their interaction can affect Caspase3 cleavage of Hax1. PMID: 26869103
    8. results suggest that miR-223 increases the sensitivity of TNBCSCs to TRAIL-induced apoptosis by targeting HAX-1 PMID: 27618431
    9. The s describe the first case series of patients with CN caused by HAX1 mutation who presented with HLH. They hypothesize that severe neutropenia persists after an HLH episode in children without FHLH mutations (especially infants) because these patients have CN caused by HAX1 mutations. PMID: 28169428
    10. Study indicates that the overexpression of HAX-1 is essential in the development of chemoresistance in breast cancer. PMID: 28347249
    11. Results show that mRNA and protein levels of HAX-1 in prostate cancer cell lines were significantly higher and inhibits cell apoptosis through caspase-9 inactivation. PMID: 26323553
    12. HAX-1 is overexpressed in hepatocellular carcinoma and promotes cell proliferation. PMID: 26339377
    13. HAX1 knockdown significantly decreased the proliferation. In addition, the expression levels of ki67 and phosphorylatedakt were inhibited following HAX1 knockdown. PMID: 26062578
    14. HAX-1 was significantly elevated in laryngeal carcinoma. PMID: 25554539
    15. s showed that HAX1 promotes auto-ubiquitination and degradation of cIAPs by facilitating the intermolecular homodimerization of RING finger domain. PMID: 25275296
    16. HAX-1 is involved in mRNA processing as an element of P-body interaction network. PMID: 25289648
    17. HAX1 mutation is associated with severe congenital neutropenia. PMID: 25284454
    18. HAX1 is a proto-oncogene in mantle cell lymphoma. PMID: 25419709
    19. anti-apoptotic role of HAX-1 versus BCL-XL in cytokine-dependent bone marrow-derived cells PMID: 24910348
    20. Genetic correction of HAX1 in induced pluripotent stem cells from a patient with severe congenital neutropenia improves defective granulopoiesis. PMID: 23975175
    21. A new homozygous HAX1 deletion (exons 2-5) was found in a French Kostmann syndrome pedigree. A homozygous frameshift mutation was found in exon 3 (c.430dupG, p.Val144fs) in a 2d pedigree. Neurological retardation associated with B isoform mutations. PMID: 24482108
    22. HAX-1 might be an important marker for tumor progression and prognosis, as well as a potential therapeutic target of Colorectal cancer PMID: 24057929
    23. Hax-1 is a family of anti- and proapoptotic regulators that may modulate cell survival and death through homo- or heterodimerization. PMID: 24347163
    24. Studies indicate that mutations in the gene encoding HAX1 were present in patients with the autosomal recessive form of severe congenital neutropenia. PMID: 24341138
    25. Hax1 physically interacts with TPC1/2 C-terminal domain. PMID: 24188827
    26. 4 ELANE mutations, 11 HAX1 mutations and 2 G6PC3 mutations have been identified in Iranian patients with severe congenital neutropenia. PMID: 23454784
    27. HAX-1 mRNA is over-expressed in esophageal squamous cell carcinoma and is prognostic factor for lymphatic metastasis and survival. PMID: 23531395
    28. HAX-1 may be involved in the regulation of expression of bound transcripts, possibly as part of the stress response. PMID: 23164465
    29. These data show that HAX1 specifically interacts with influenza A virus polymerase PA in vitro and in vivo and that HAX1 interacts with the nuclear localization signal domain of PA. PMID: 23055567
    30. Hax-1 is a short-lived protein and that its PEST sequence dependent fast degradation by the proteasome. PMID: 22827267
    31. We also confirmed the interaction of HAX-1 and hSav1 in mammalian cells. PMID: 22570112
    32. HAX-1 promotes the proliferation, chemoresistance, invasion, and tumorigenicity of esophageal squamous cell carcinoma. PMID: 22451114
    33. Data suggest that Hax-1 is a new PrP-interacting partner that may play role in cell oxidative stress and anti-apoptosis physiologically and cell damage pathologically. PMID: 21301993
    34. hSav1 interacts with HAX1 and attenuates its protective role against apoptosis in MCF-7 breast cancer cells. PMID: 21567072
    35. Novel HAX1 gene mutations are associated with neurodevelopmental abnormalities in two Italian patients with severe congenital neutropenia. PMID: 20065084
    36. Hax1 is a novel regulator of neutrophil uropod detachment and chemotaxis through RhoA PMID: 21518791
    37. Our resultsvindicate that HAX-1 may not be a candidate gene for psoriasis susceptibility in the Chinese Han population. PMID: 21109726
    38. Full-length Grb7 and Hax-1 interact in mammalian cells and Grb7 is tyrosine phosphorylated. PMID: 20665473
    39. Biallelic mutations in the antiapoptotic gene HAX1 were identified in patients with autosomal recessive severe congenital neutropenia. PMID: 21206270
    40. identified consanguineous family with 2 patients with severe congenital neutropenia and neurological disease caused by novel, homozygous genomic deletion including exons 4-7 of the HAX1 gene; quantitative MRI showed alteration in cerebral proton density PMID: 21108402
    41. analysis of HAX-1 overexpression, splicing and cellular localization in tumors PMID: 20196840
    42. HAX-1 is a multifaceted antiapoptotic protein localizing in the mitochondria and the sarcoplasmic reticulum of striated muscle cells PMID: 19913549
    43. The N(pro)-HAX-1 interaction was confirmed using co-precipitation assays. PMID: 20631090
    44. describe congenital neutropenia patients with mutations in two candidate genes each,HAX1 and G6PC3, including 6 novel mutations PMID: 20220065
    45. This study is the first to demonstrate GrB activity within the mitochondrion and to identify Hax-1 cleavage as a novel mechanism for GrB-mediated mitochondrial depolarization. PMID: 20388708
    46. PELO is subcellularly localized at the actin cytoskeleton, interacts with HAX1, EIF3G and SRPX proteins and that this interaction occurs at the cytoskeleton; this interaction may facilitate PELO to detect and degrade aberrant mRNAs. PMID: 20406461
    47. HAX-1 suppresses the polyubiquitination of XIAP; formation of the HAX-1-XIAP complex inhibits apoptosis by enhancing the stability of XIAP against proteosomal degradation. PMID: 20171186
    48. study suggests that the novel missense c.421T>C mutation in the HAX1 gene produces a milder form of severe congenital neutropenia without apparent developmental or neurological manifestations PMID: 19796188
    49. Interacts with the alpha subunit of G protein G13 to promote cell migration. PMID: 15339924
    50. results indicate a different function and mechanism of Hax1 in apoptosis and re-opens the question of whether mammalian PARL, in addition to apoptosis, regulates mitochondrial stress response through Omi/HtrA2 processing. PMID: 19680265

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  • 相关疾病：
    Neutropenia, severe congenital 3, autosomal recessive (SCN3)
  • 亚细胞定位：
    Mitochondrion. Endoplasmic reticulum. Nucleus membrane. Cytoplasmic vesicle. Cytoplasm, cell cortex. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Sarcoplasmic reticulum. Cytoplasm, P-body.; [Isoform 1]: Cytoplasm. Nucleus.; [Isoform 3]: Cytoplasm. Nucleus.; [Isoform 4]: Cytoplasm. Nucleus.; [Isoform 5]: Cytoplasm.
  • 蛋白家族：
    HAX1 family
  • 组织特异性：
    Ubiquitous. Up-regulated in oral cancers.
  • 数据库链接：

    HGNC: 16915

    OMIM: 605998

    KEGG: hsa:10456

    STRING: 9606.ENSP00000329002

    UniGene: Hs.199625