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HECTD1 Antibody

  • 货号：
    CSB-PA010273GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9ULT8
  • 基因名：
  • 别名：
    E3 ligase for inhibin receptor antibody; E3 ubiquitin protein ligase HECTD1 antibody; E3 ubiquitin-protein ligase HECTD1 antibody; EULIR antibody; HECD1_HUMAN antibody; HECT domain containing protein 1 antibody; HECT domain-containing protein 1 antibody; HECTD1 antibody; KIAA1131 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Human HECTD1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC,IF
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates 'Lys-63'-linked polyubiquitination of HSP90AA1 which leads to its intracellular localization and reduced secretion. Negatively regulating HSP90AA1 secretion in cranial mesenchyme cells may impair their emigration and may be essential for the correct development of the cranial neural folds and neural tube closure.
  • 基因功能参考文献：
    1. HECTD1 may be involved in the regulation of ABCA1-mediated cholesterol export from unloaded macrophages to apoA-I. PMID: 29306077
    2. Hectd1 regulates the protein level of IQGAP1 through ubiquitination. PMID: 28073378
    3. our high-resolution structures show a new fold composed of five small helices where H3 and H4 are tilted in a novel arrangement; we call this fold the Basic Tilted Helix Bundle (BTHB) domain. PMID: 24667607
    4. HectD1 promotes the APC-Axin interaction to negatively regulate Wnt signaling. PMID: 23277359
  • 蛋白家族：
    UPL family, K-HECT subfamily
  • 数据库链接：

    HGNC: 20157

    KEGG: hsa:25831

    STRING: 9606.ENSP00000382269

    UniGene: Hs.708017