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HERPUD1 Antibody

  • 货号：
    CSB-PA622984ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: HERPUD1 antibody at 2.07μg/ml
      Lane 1: HepG2 whole cell lysate
      Lane 2: Hela whole cell lysate
      Lane 3: PC-3 whole cell lysate
      Lane 4: 293T whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 44, 27, 41 kDa
      Observed band size: 44 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) HERPUD1 Polyclonal antibody
  • Uniprot No.：
    Q15011
  • 基因名：
  • 别名：
    HERPUD1; HERP; KIAA0025; MIF1; Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein; Methyl methanesulfonate; MMF-inducible fragment protein 1
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein (1-240AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Could enhance presenilin-mediated amyloid-beta protein 40 generation. Binds to ubiquilins and this interaction is required for efficient degradation of CD3D via the ERAD pathway.
  • 基因功能参考文献：
    1. This study showed that Herp stability was regulated by synoviolin through lysine ubiquitination-independent proteasomal degradation. PMID: 29863080
    2. HERP plays an important role in the regulation of host innate immunity in response to ER stress during the infection of RNA viruses. PMID: 28954889
    3. results indicated that low expression of miR-9-3p results in a high level of Herpud1, which may protect against apoptosis in glioma PMID: 28430789
    4. Thus, our findings indicated that NQO1 could stabilize Herp protein expression via indirect regulation of synoviolin. PMID: 27084451
    5. The s found that the CREB3/Herp pathway limited the increase in cytosolic Ca2+ concentration and apoptosis early in poliovirus infection and this may reduce the extent of poliovirus-induced damage to the central nervous system during poliomyelitis. PMID: 27405867
    6. HERPUD1 SNPs are highly associated with polypoidal choroidal vasculopathy. PMID: 26823705
    7. concluded that the HERPUD1-mediated cytoprotective effect against oxidative stress depends on the ITPR and Ca(2+) transfer from the endoplasmic reticulum to mitochondria PMID: 26616647
    8. The results indicate that Nrf1 is a transcriptional activator of Herpud1 expression during ER stress, and they suggest Nrf1 is a key player in the regulation of the ER stress response in cells. PMID: 25637874
    9. Herp operates as a relevant factor in the defense against glucose starvation by modulating autophagy levels. PMID: 24120520
    10. Together with histological grade, increased co-expression of MIF and MMP9 in tumor might be a valuable predictor for recurrence, especially for benign meningiomas PMID: 23372434
    11. binding of Herp to Hrd1-containing ERAD complexes positively regulates the ubiquitylation activity of these complexes, thus permitting survival of the cell during ER stress. PMID: 21149444
    12. The results suggest that ERAD molecule Herp may delay the degradation of cytosolic proteins at the ubiquitination step. PMID: 20604806
    13. Herp mimics structural determinants of DNA immunologically and can be immunogenic in vivo. Thus, Herp represents a candidate autoantigen for anti-DNA antibodies. PMID: 20147634
    14. Data show that that 4-trifluoromethyl-celecoxib can inhibit secretion but not transcription of IL-12 (p35/p40) and IL-23 (p40/p19 heterodimers), and that this is associated with HERP function in the endoplasmic reticulum. PMID: 20054003
    15. enhances presnilin-mediated generation of amyloid beta protein PMID: 11799129
    16. upregulation by Wnt-1 PMID: 12153396
    17. may associate through its ubiquitin-like domain with the 26S proteasome, in this way connecting the protein degradation machinery to the ER membrane and resulting in an efficient ERAD PMID: 12370023
    18. The ubiquitin-like domain of Herp most likely plays a role in the regulation of the intracellular level of Herp under ER stress PMID: 14550564
    19. Results report the identification of Herp, a gene involved in ER stress-associated protein degradation (ERAD), as a direct target of Luman. PMID: 16940180
    20. We identified the transcription factor binding site AARE (amino acid response element) by mutational analysis involved in Herp induction in SH-SY5Y cells, and the more significant role of the CREB binding site compared to AARE in HEK 293T cells. PMID: 17020760
    21. Herp is in a complex with ubiquitinated proteins and with the 26S proteasome, suggesting that it plays a role in linking substrates with the proteasome. PMID: 18042451
    22. Our data suggest that Herp binding to ubiquilin proteins plays an important role in the ERAD pathway and that ubiquilins are specifically involved in degradation of only a subset of ubiquitinated targets, including Herp-dependent ERAD substrates. PMID: 18307982
    23. Type II alcoholic patients had a statistically significant higher expression of Herp mRNA due to upregulation of the expression of this neuroprotective cell non-chaperone by toxic effects of ethanol. PMID: 19251110
    24. the underlying molecular mechanism(s) whereby Herp counteracts Ca(2+) disturbances will provide insights into the molecular cascade of cell death in dopaminergic neurons PMID: 19447887
    25. Herp may play a role in the initiation of the well-known inflammation-like changes in Parkinson disease substantia nigra and serve as a molecular link between degeneration and neuroinflammation in Parkinson disease PMID: 19788048
    26. Expression of Herp protein is up-regulated in response to ER stress, including homocysteine. PMID: 17020760

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  • 亚细胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 组织特异性：
    Widely expressed; in the brain, expression seems to be restricted to neurons and vascular smooth muscle cells. Present in activated microglia in senile plaques in the brain of patients with Alzheimer disease.
  • 数据库链接：

    HGNC: 13744

    OMIM: 608070

    KEGG: hsa:9709

    STRING: 9606.ENSP00000409555

    UniGene: Hs.146393