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HES5 Antibody

  • 货号：
    CSB-PA729212LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA729212LA01HU diluted at 1:400 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) HES5 Polyclonal antibody
  • Uniprot No.：
    Q5TA89
  • 基因名：
  • 别名：
    bHLHb38 antibody; Class B basic helix-loop-helix protein 38 antibody; Hairy and enhancer of split 5 antibody; Hairy/Enhancer of spli, Drosophila, homolog of, 5 antibody; HES 5 antibody; hes family bHLH transcription factor 5 antibody; Hes5 antibody; HES5 protein antibody; HES5_HUMAN antibody; MGI:104876 antibody; Transcription factor HES-5 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Transcription factor HES-5 protein (1-166AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，HES5 Antibody (CSB-PA729212LA01HU)，的标记方式是Non-conjugated。对于HES5 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA729212LB01HU HES5 Antibody, HRP conjugated ELISA
    FITC CSB-PA729212LC01HU HES5 Antibody, FITC conjugated
    Biotin CSB-PA729212LD01HU HES5 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:200-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transcriptional repressor of genes that require a bHLH protein for their transcription. Plays an important role as neurogenesis negative regulator.
  • 基因功能参考文献：
    1. HES5 might contribute to the proliferation of non-small cell lung cancer by STAT3 signaling. PMID: 27878283
    2. that suppression of the HES5 leading to inhibition of proliferation may be one of the mechanisms against Hepatocellular carcinoma PMID: 26342546
    3. HES5 silencing is an early and recurrent change in prostate tumourigenesis PMID: 25560400
    4. these data identify HES5 as a key mediator of the Wnt-3a proneurogenic effect occurring independently of the classical Wnt/beta-catenin signaling cascade thus further deciphering crosstalk mechanisms of Wnt and Notch signaling pathways regulating cell fate PMID: 24548083
    5. the downstream Notch signalling effector HES5 directly represses transcription of the E3 ligase Fbw7beta. PMID: 23776410
    6. Notch3 and Hes5 are hypermethylated in human B cell acute lymphoblastic leukemia (ALL). PMID: 23637910
    7. Hes5 overactivation is associated with cell differentiation, thereby resulting in uterine carcinogenesis. PMID: 21495212
    8. In this study, HES 5 transcription factor was detected in the lining epithelium of human periapical cysts with limited inflammation, showing Notch pathway activation in those cells. PMID: 21238798
    9. The expression of HES5 in adenocarcinoma was significantly higher than those in adenoma and normal control PMID: 20091184
    10. For marking and purifying neural stem cells to ascertain whether differences exist, we generated transgenic mice using promoters from Hes genes (pHes1 or pHes5) to drive expression of destabilized enhanced green fluorescent protein. PMID: 16214363
    11. Notch protein binding to Hes5-GFP is extinguished fast and recovered slowly, whereas Hes1-GFP is inhibited late and recovered quickly PMID: 16365048
    12. The HLH gene HES5 on the other hand was only detected in chondrocytes. PMID: 17072841
    13. Human HES5 gene is coupled to the Notch receptor family and expression of Notch markers (including HES5) decreases during cartilage differentiation. PMID: 17093926
    14. expression significantly higher in squamous cervical carcinoma than in CIN as well as higher in CIN than normal cervical epithelia PMID: 17388915
    15. Data show that HES5 are abundantly expressed in osteoarthritis. PMID: 18354251
    16. regulates brain development process.[review] PMID: 18524252

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Expressed in fetal heart and brain tumors.
  • 数据库链接：

    HGNC: 19764

    OMIM: 607348

    KEGG: hsa:388585

    STRING: 9606.ENSP00000367714

    UniGene: Hs.57971