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HIP1R Antibody

  • 货号：
    CSB-PA010366LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Rat brain tissue
      All lanes: HIP1R antibody at 2.4μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 120, 71 kDa
      Observed band size: 120 kDa
    • IHC image of CSB-PA010366LA01HU diluted at 1:800 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA010366LA01HU diluted at 1:800 and staining in paraffin-embedded human pancreatic tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) HIP1R Polyclonal antibody
  • Uniprot No.：
    O75146
  • 基因名：
    HIP1R
  • 别名：
    FLJ14000 antibody; FLJ27022 antibody; HIP-12 antibody; Hip1 related antibody; HIP1-related protein antibody; HIP12 antibody; HIP1R antibody; HIP1R_HUMAN antibody; HIP3 antibody; Huntingtin Interacting Protein 1 Related antibody; Huntingtin interacting protein 12 antibody; Huntingtin-interacting protein 1-related protein antibody; Huntingtin-interacting protein 12 antibody; ILWEQ antibody; KIAA0655 antibody; MGC47513 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Rat
  • 免疫原：
    Recombinant Human Huntingtin-interacting protein 1-related protein (304-487AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，HIP1R Antibody (CSB-PA010366LA01HU)，的标记方式是Non-conjugated。对于HIP1R Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA010366LB01HU HIP1R Antibody, HRP conjugated ELISA
    FITC CSB-PA010366LC01HU HIP1R Antibody, FITC conjugated
    Biotin CSB-PA010366LD01HU HIP1R Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:500-1:1000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis.
  • 基因功能参考文献：
    1. HIP1R rescued miR-23b/-27b-mediated repression of migration in prostate cancer cells. HIP1R mRNA levels were decreased in seminal vesicle tissue from mice bearing miR-23b/-27b-transduced prostate cancer cell xenografts compared with scrambled controls, suggesting HIP1R is a key functional target of miR-23b/-27b. PMID: 26898757
    2. our findings support the conclusion that the rs12817488 in CCDC62/HIP1R polymorphism may increase the risk of Parkinson's disease in the Chinese Han population. PMID: 25818163
    3. We conclude that HIP1R expression is strongly indicative of survival in diffuse large B-cell lymphoma PMID: 26341140
    4. STK39 (rs2102808) and CCDC62/HIP1R (rs12817488) do not appear to influence PD risk. PMID: 24312176
    5. HIP1r plays an important role in regulating the attachment of spindle microtubules to chromosomes during mitosis, an event that is required for accurate congression and segregation of chromosomes. PMID: 21189155
    6. HIP1 and HIP12 display differential binding to F-actin, AP2, and clathrin. Identification of a novel interaction with clathrin light chain. (HIP12) PMID: 11889126
    7. both HIP1r and HIP1 bind inositol lipids via their epsin N-terminal homology (ENTH) domains PMID: 14732715
    8. Hip1R has a role in making the interaction between actin and the endocytic machinery functional and transient PMID: 14742709
    9. The F-actin binding capacity of Hip12 is regulated by intrasteric occlusion of primary actin-binding determinants within the Hip12 I/LWEQ module. PMID: 15581353
    10. the stability of intergenerational transmission of a variable number tandem repeat (VNTR) polymorphism, found in the Huntingtin interacting protein-1 related gene (HIP12/HIP1R) that is mapped to the chromosome 12q24.31 region. PMID: 15588756
    11. characterize the F-actin-binding region of HIP1R, termed the talin-HIP1/R/Sla2p actin-tethering C-terminal homology (THATCH) domain PMID: 16415883
    12. Human HIP1 transgenic Hip1/Hip1r knockout mice are completely free from dwarfism and spinal defects. PMID: 17452370
    13. Neuronal dysfunction in transgenic Caenorhabditis elegans expressing mutant N-terminal huntingtin is specifically enhanced by hipr-1 loss of function. PMID: 17928447
    14. in mammalian cells CLCs function in intracellular membrane trafficking by acting as recruitment proteins for HIP1R, enabling HIP1R to regulate actin assembly on clathrin-coated structures PMID: 18165318
    15. Actin binding by Hip1 (huntingtin-interacting protein 1) and Hip1R (Hip1-related protein) is regulated by clathrin light chain PMID: 18790740
    16. This study provided the previously unknown function of HIP1R involved in the intrinsic cell death pathway and further explored possible mechanisms by which HIP1R induces cell death. PMID: 19255499

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  • 亚细胞定位：
    Cytoplasm, perinuclear region. Endomembrane system. Cytoplasmic vesicle, clathrin-coated vesicle membrane. Note=Membrane-associated protein, mainly localized at the endocytic compartments and in the perinuclear region.
  • 蛋白家族：
    SLA2 family
  • 组织特异性：
    Brain, heart, kidney, pancreas, and liver, but not in lung or placenta.
  • 数据库链接：

    HGNC: 18415

    OMIM: 605613

    KEGG: hsa:9026

    STRING: 9606.ENSP00000253083

    UniGene: Hs.524815