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HLA-DOA Antibody

  • 货号：
    CSB-PA113671
  • 规格：
    ￥2024
  • 图片：
    • Western blot analysis of extracts from COLO cells, using HLA-DOA antibody.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) HLA-DOA Polyclonal antibody
  • Uniprot No.：
    P06340
  • 基因名：
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from internal of Human HLA-DOA.
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells. Modifies peptide exchange activity of HLA-DM.
  • 基因功能参考文献：
    1. Contribution of a Non-classical HLA Gene, HLA-DOA, to the Risk of Rheumatoid Arthritis PMID: 27486778
    2. significant association was found between white wine liking and rs9276975:C>T polymorphism in the HLA-DOA gene. PMID: 25758996
    3. TAP2, HLA-DOA, HLA-DOB, and tapasin loci are novel candidate regions for susceptibility to HCV infection and viral clearance in the Chinese population PMID: 25874709
    4. HLA-DO regulates surface presentation of human leukocyte antigen class II-restricted antigens on B cell malignancies. PMID: 24530695
    5. HLA-DOA, HLA-DRA, and HLA-DQA1 associated with spontaneous autoimmunity PMID: 24384427
    6. results show that HLA-DO inhibits HLA-DM function by acting as a substrate mimic, and the findings also limit the possible functional roles for HLA-DO in antigen presentation PMID: 23222639
    7. analysis of the HLA-DO/HLA-DM complex by FRET and mutagenesis PMID: 22733780
    8. HLA-DOA mutations were analyzed for association with autoimmune diseases and B-cell leukemias. PMID: 12439622
    9. In transgenic mice expressing human HLA-DOA & HLA-DOB from a DC-specific promoter, as DO increased, A(b)-CLIP increased & class II-peptides decreased. DO impaired H-2M function, causing Ag-specific downmodulation of class II Ag processing/presentation. PMID: 15265882
    10. These results show that transduced DO modulates antigen presentation in human mature MoDC, evoking the possible use of this chaperone for immunotherapy. PMID: 15817706
    11. four novel HLA-DOA alleles, DOA*010106, DOA*0102, DOA*0103, and DOA*0104N, were identified by sequence-based typing PMID: 16101837
    12. minor allele of the SNP rs9296068 is significantly associated with liver transplantation rejection and with enhanced B-lymphocyte participation in rejection, likely because of a dysfunctional HLA-DOA gene product. PMID: 18639552
    13. HLA-DOA polymorphisms are associated with Diabetes Mellitus, Type 1. PMID: 19458622

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  • 亚细胞定位：
    Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=Complexes with HLA-DM molecule during intracellular transport and in endosomal/lysosomal compartments. Heterotetramerization is necessary to exit the ER.
  • 蛋白家族：
    MHC class II family
  • 数据库链接：

    HGNC: 4936

    OMIM: 142930

    KEGG: hsa:3111

    STRING: 9606.ENSP00000229829

    UniGene: Hs.631991