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HLA-DOB Antibody

  • 货号：
    CSB-PA002935
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of 293 cells using HLA-DOβ Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    P13765
  • 基因名：
  • 别名：
    HLA-DOBHLA class II histocompatibility antigen antibody; DO beta chain antibody; MHC class II antigen DOB antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the N-terminal region of Human HLA-DOβ.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells. Modifies peptide exchange activity of HLA-DM.
  • 基因功能参考文献：
    1. results indicate that HLA-DOB is co-inherited with DQA2-B2 genes and thus may contribute to HCV and HBV persistence PMID: 28813660
    2. HLA-DO beta-chain antigens are ubiquitinated by MARCH family E3 ligases 1, 8, and 9. PMID: 23400868
    3. HLA-DOB mutations were analyzed for association with autoimmune diseases and B-cell leukemias. PMID: 12439622
    4. A new DOB allele, DOB*010103, was identified in the Korean population during sequence-based HLA-DOB typing. PMID: 15730525
  • 亚细胞定位：
    Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=Complexes with HLA-DM molecule during intracellular transport and in endosomal/lysosomal compartments. Heterotetramerization is necessary to exit the ER.
  • 蛋白家族：
    MHC class II family
  • 数据库链接：

    HGNC: 4937

    OMIM: 142920

    KEGG: hsa:3112

    STRING: 9606.ENSP00000390020

    UniGene: Hs.1802