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  4. HLX Antibody

HLX Antibody

  • 货号：
    CSB-PA002936
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of COLO205 cells using HLX1 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q14774
  • 基因名：
    HLX
  • 别名：
    H2.0 like homeo box 1 antibody; H2.0 like homeobox 1 antibody; H2.0 like homeobox 1 Drosophila antibody; H2.0-like homeobox protein antibody; HB24 antibody; HLX antibody; HLX_HUMAN antibody; Homeobox protein HB24 antibody; Homeobox protein HLX1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human HLX1.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transcription factor required for TBX21/T-bet-dependent maturation of Th1 cells as well as maintenance of Th1-specific gene expression. Involved in embryogenesis and hematopoiesis.
  • 基因功能参考文献：
    1. An important association between HLX transcription factor expression and abnormal human placental development in discordant twin pregnancies. PMID: 29212571
    2. HLX is a homeobox transcription factor gene which is relatively conserved across species. Hlx homozygous null mice have a short bowel and reduced muscle cells in the diaphragm, closely resembling the anomalies in the two fetuses and we therefore suggest that the HLX mutation in this family could explain the fetal findings PMID: 28898547
    3. Prdm16 interacts with the transcription factor Hlx, which is stabilized in response to beta3-adrenergic signaling, to increase thermogenic gene expression and mitochondrial biogenesis in subcutaneous WAT. PMID: 28701693
    4. HLX1 is significantly downregulated in HCC and suggests that HLX1 has suppressive effects on HCC growth and metastasis. Accordingly, HLX1 may act as a tumor suppressor in HCC. PMID: 26631039
    5. Studies have identified HLX as a novel key transcription factor involved in the regulation of early hematopoiesis and AML pathogenesis. PMID: 23888188
    6. The expression levels of Hlx, T-bet, and IFN-gamma were significantly decreased. PMID: 23243425
    7. Data suggest that HLX1 is downstream mediator of hepatocyte growth factor- (HGF-) induced cell survival, cell proliferation, and invasive properties of trophoblast cells; thus, both HGF and HLX1 appear to be involved in normal placental development. PMID: 22989111
    8. This study identifies HLX as a key regulator in immature hematopoietic and leukemia cells and as a prognostic marker and therapeutic target in acute myeloid leukemia. PMID: 22897850
    9. This study investigated the influence of TBX21 and HLX1 single nucleotide polymorphisms (SNPs), which have previously been shown to be associated with asthma, on T(H)1/T(H)2 lineage cytokines at birth. PMID: 22303482
    10. a functional polymorphism in HLX in combination with the TBX21 polymorphism is also associated with the prognosis of Graves' disease. PMID: 22014209
    11. These data suggest that HLX may function to balance attractive with repulsive vessel guidance by up-regulating UNC5B and to down-modulate sprouting under normoxic conditions. PMID: 21224470
    12. HLX is a mediator of HGF/c-met-dependent trophoblast migration but is not involved in the regulation of trophoblast invsion. PMID: 20554918
    13. Cell cycle regulatory genes RB1, MYC, CCNB1, ELK1, JUN, and CDKN1C, which control important trophoblast cell functions, are targets of HLX. PMID: 20008130
    14. Decreased HLX1 expression is associated with idiopathic fetal growth restriction PMID: 16436665
    15. Hlx expression in activated NK cells temporally controls and limits the monokine-induced production of interferon-gamma. PMID: 17110450
    16. We have shown for the first time that a homeobox gene, HLX1, is a downstream effector gene of CSF-1, that HLX1 regulates placental cell proliferation and that CSF-1 acts, at least in part, through HLX1 to control cell proliferation. PMID: 17532041
    17. HLX is primarily expressed in cytotrophoblast cell types in the human placenta and propose that HLX is involved in cytotrophoblast proliferation and downregulation of cell differentiation PMID: 18402755
    18. polymorphisms in the HLX1 gene increase the risk for childhood asthma. PMID: 19038437
    19. gene variants influence the development of childhood asthma PMID: 19295429
    20. A risk score model indicates that TBX21 and HLX1 polymorphisms may have synergistic effects on asthma risk. PMID: 19362357
    21. Sequence variants in the HLX gene at chromosome 1q41-1q42 in patients with diaphragmatic hernia PMID: 19459883

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    H2.0 homeobox family
  • 组织特异性：
    Low level in normal B and T-cells, high level in activated lymphocytes and monocytes. Also found in thymus, tonsil, bone marrow, developing vessels, and fetal brain.
  • 数据库链接：

    HGNC: 4978

    OMIM: 142995

    KEGG: hsa:3142

    STRING: 9606.ENSP00000355870

    UniGene: Hs.74870