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  4. HM13 Antibody

HM13 Antibody

  • 货号：
    CSB-PA010522GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q8TCT9
  • 基因名：
    HM13
  • 别名：
    dJ324O17.1 antibody; H13 antibody; hIMP1 antibody; Histocompatibility (minor) 13 antibody; HM13 antibody; HM13_HUMAN antibody; IMP-1 antibody; IMP1 antibody; IMPAS antibody; IMPAS-1 antibody; Intramembrane protease 1 antibody; Intramembrane protease antibody; Minor histocompatibility antigen 13 antibody; Minor histocompatibility antigen H13 antibody; MSTP086 antibody; OTTHUMP00000030527 antibody; OTTHUMP00000030528 antibody; OTTHUMP00000030530 antibody; OTTHUMP00000214528 antibody; Presenilin-like protein 3 antibody; PSENL3 antibody; PSL3 antibody; Signal peptide peptidase antibody; Signal peptide peptidase beta antibody; SPP antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Human HM13
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm. Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides. May be necessary for the removal of the signal peptide that remains attached to the hepatitis C virus core protein after the initial proteolytic processing of the polyprotein. Involved in the intramembrane cleavage of the integral membrane protein PSEN1. Cleaves the integral membrane protein XBP1 isoform 1 in a DERL1/RNF139-dependent manner. May play a role in graft rejection.
  • 基因功能参考文献：
    1. Preproinsulin signal peptide epitopes are processed by SPP and loaded for HLA-guided immune recognition via pathways that are enhanced during type 1 diabetes pathogenesis. PMID: 29343547
    2. Though far from complete, our knowledge on pathophysiological functions of SPP/SPPL proteases, in particular based on studies in mice, has been significantly increased over the last years. Based on this, inhibition of distinct SPP/SPPL proteases has been proposed as a novel therapeutic concept e.g. for the treatment of autoimmunity and viral or protozoal infections, as we will discuss in this review. PMID: 28624439
    3. The domains involved in HO-1 translocation have been identified, and it was shown that SPP-mediated HO-1 cleavage is isoform-specific (HO-1 vs HO-2) and independent of heme oxygenase activity. PMID: 29155886
    4. This study identifies that SPP affects EGFRvIII secretion profiles and thus promotes tumor progression, providing further understanding of the formation of secreted vesicles and driving role of EGFRvIII in Glioblastoma. PMID: 28198167
    5. structure of human SPP [SPP] PMID: 21636854
    6. identified human signal peptide peptidase as a polytopic membrane protein with sequence motifs characteristic of the presenilin-type aspartic proteases [SPP] PMID: 12077416
    7. identification and molecular cloning; expression analysis of the hIMP1 gene (located on chromosome 20) was performed in human cell tissues and transfected cell cultures [IMP1] PMID: 12139484
    8. widespread expression of SPP in many tissues PMID: 12972007
    9. signal peptide peptidase forms a homodimer that is labeled by an active site-directed gamma-secretase inhibitor PMID: 14704149
    10. IMP1 is a bi-aspartic polytopic protease capable of cleaving transmembrane proteins such as presenilin 2. PMID: 14741365
    11. The peptide structure corresponding to the C-terminal residues from H13 ribosomal protein was determined using magnetic resonance spectroscopy. PMID: 14988012
    12. data implicate SPP in the US2 pathway and indicate the possibility of a previously unknown function for this intramembrane-cleaving aspartic protease in dislocation from the endoplasmic reticulum PMID: 16738546
    13. Upon isolation of membranes and solubilization with detergent, the biochemical characteristics of SPP are remarkably similar to gamma-secretase. PMID: 16834339
    14. Compares a variant from the mouse ortholog to the human gene. PMID: 16730383

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  • 亚细胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein; Lumenal side.; [Isoform 4]: Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Peptidase A22B family
  • 组织特异性：
    Widely expressed with highest levels in kidney, liver, placenta, lung, leukocytes and small intestine and reduced expression in heart and skeletal muscle. Expressed abundantly in the CNS with highest levels in thalamus and medulla.
  • 数据库链接：

    HGNC: 16435

    OMIM: 607106

    KEGG: hsa:81502

    UniGene: Hs.373741