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HMG20B Antibody

  • 货号：
    CSB-PA001040
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of AD293 cells using BRAF35 Polyclonal Antibody
    • Western Blot analysis of HELA 293T cells using BRAF35 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q9P0W2
  • 基因名：
    HMG20B
  • 别名：
    BRAF25 antibody; BRAF35 antibody; BRCA2 associated factor 35 antibody; BRCA2-associated factor 35 antibody; High Mobility Group Protein 20B antibody; HM20B_HUMAN antibody; HMG box containing protein 20B antibody; HMG box-containing protein 20B antibody; HMG domain-containing protein 2 antibody; HMG domain-containing protein HMGX2 antibody; HMG20B antibody; SMARCE1-related protein antibody; SMARCE1r antibody; sox like antibody; Sox like transcriptional factor antibody; Sox-like transcriptional factor antibody; SOXL antibody; Structural DNA binding protein BRAF35 antibody; Structural DNA-binding protein BRAF35 antibody; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the N-terminal region of Human BRAF35.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Required for correct progression through G2 phase of the cell cycle and entry into mitosis. Required for RCOR1/CoREST mediated repression of neuronal specific gene promoters.
  • 基因功能参考文献：
    1. Our data reveal a novel role for MID1 and for atypical ubiquitination in balancing BRAF35 presence, and likely its activity, within nuclear and cytoplasmic compartments PMID: 28760657
    2. Fresh insight into the mechanism by which the HMG20b-BRCA2 complex controls mitotic cell division, and implicate heterozygous HMG20b mutations affecting cytokinesis regulation in the genesis of human cancers. PMID: 25486196
    3. HMG20B/BRAF35 forms heterodimers with HMG20A/iBRAF. Heterodimerization impairs HMG20B/BRAF35 sumoylation and interaction with the LSD1-CoREST complex. PMID: 22570500
    4. a novel function for HMG20b in cytokinesis is regulated by its interaction with the BRC repeats of BRCA2 PMID: 21399666
    5. beta-dystrobrevin interacts with the HMG20 proteins iBRAF and BRAF35 PMID: 20530487
    6. molecular cloning, nucleotide and amino acid sequencing PMID: 11997092
    7. complex containing histone deacetylase complex containing histone deacetylase mediates repression of neuronal-specific genes. PMID: 12032298
    8. molecular Cloning of BRAF25, an alternatively spliced protein of BRAF35 PMID: 12083779
    9. Results demonstrating association of BRAF35 with KIF4 through the interaction of their respective alpha-helical coiled-coil domains is unique so far in mammals. PMID: 12809554
    10. we have examined Sox gene expression in 60 human primary gliomas. Transcripts from each of the six group E and group D genes were expressed in gliomas of various types and malignancy grades PMID: 17961134

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  • 亚细胞定位：
    Nucleus. Chromosome. Note=Localized to condensed chromosomes in mitosis in conjunction with BRCA2.
  • 组织特异性：
    Ubiquitously expressed in adult tissues.
  • 数据库链接：

    HGNC: 5002

    OMIM: 605535

    KEGG: hsa:10362

    STRING: 9606.ENSP00000328269

    UniGene: Hs.406534