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HMGN3 Antibody

  • 货号：
    CSB-PA623009LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA623009LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) HMGN3 Polyclonal antibody
  • Uniprot No.：
    Q15651
  • 基因名：
    HMGN3
  • 别名：
    DKFZp686E20226 antibody; FLJ42187 antibody; High mobility group nucleosomal binding domain 3 antibody; High mobility group nucleosome-binding domain-containing protein 3 antibody; HMGN3 antibody; HMGN3_HUMAN antibody; OTTHUMP00000016772 antibody; OTTHUMP00000016773 antibody; PNAS 24 antibody; PNAS 25 antibody; PNAS24 antibody; PNAS25 antibody; Thyroid hormone receptor interacting protein 7 antibody; Thyroid receptor-interacting protein 7 antibody; TR-interacting protein 7 antibody; TRIP 7 antibody; TRIP-7 antibody; TRIP7 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human High mobility group nucleosome-binding domain-containing protein 3 protein (1-77AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，HMGN3 Antibody (CSB-PA623009LA01HU)，的标记方式是Non-conjugated。对于HMGN3 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA623009LB01HU HMGN3 Antibody, HRP conjugated ELISA
    FITC CSB-PA623009LC01HU HMGN3 Antibody, FITC conjugated
    Biotin CSB-PA623009LD01HU HMGN3 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function.
  • 基因功能参考文献：
    1. The SNPs in the region of HMGN3 gene formed a tightly combined haplotype block in both Chinese and Caucasians. The results suggest that the genomic region containing HMGN3 gene may be associated with spine BS in Chinese. PMID: 21947420
    2. loss of HMGN3 impairs glucose-stimulated insulin secretion and leads to a diabetic phenotype. PMID: 19651901
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    HMGN family
  • 组织特异性：
    Expressed in kidney, lung, pancreas, testis, skeletal muscle, heart, thyroid gland, pituitary gland, prostate and uterus. Low expression in liver, spleen, placenta and ovaries.
  • 数据库链接：

    HGNC: 12312

    OMIM: 604502

    KEGG: hsa:9324

    STRING: 9606.ENSP00000341267

    UniGene: Hs.77558