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HMGN5 Antibody

  • 货号：
    CSB-PA975139
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA975139(HMGN5 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    P82970
  • 基因名：
    HMGN5
  • 别名：
    High mobility group nucleosome binding domain 5 antibody; High mobility group nucleosome-binding domain-containing protein 5 antibody; Hmgn5 antibody; HMGN5_HUMAN antibody; NBP 45 antibody; NSBP 1 antibody; NSBP1 antibody; Nucleosomal binding protein 1 antibody; Nucleosome binding protein 1 antibody; Nucleosome-binding protein 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthetic peptide of Human HMGN5
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:5000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Preferentially binds to euchromatin and modulates cellular transcription by counteracting linker histone-mediated chromatin compaction.
  • 基因功能参考文献：
    1. Findings suggest that a miR-140-5p/HMGN5/autophagy regulatory loop plays a critical role in chemoresistance in osteosarcoma. In conclusion, our data elucidated that miR-140-5p promoted autophagy mediated by HMGN5 and sensitized osteosarcoma cells to chemotherapy. PMID: 28341864
    2. High HMGN5 expression is associated with osteosarcoma invasion. PMID: 28627703
    3. We observed decreased miR-409-3p expression in glioma, and overexpression of miR-409-3p repressed glioma cell invasion and proliferation by targeting HMGN5, an oncogene associated with glioma PMID: 28109076
    4. HMGN5 regulated the expression of multidrug resistance 1, cyclin B1, and Bcl-2. PMID: 28914995
    5. NSBP1 was highly expressed in NSCLC cells. NSBP1 siRNA knockdown suppressed NSCLC cell proliferation and invasion. miR326 has a putative binding site in the NSBP1 3'UTR. NSBP1 overexpression abolished miR326 inhibition of cyclin B1 and MMP9 expression. PMID: 26548724
    6. HMGN5 overexpression is correlated with advanced pathological grade and poorer prognosis in meningiomas PMID: 26315299
    7. Decreased miR-340 expression may contribute to the development and progression of prostate cancer through a mechanism that involves HMGN5. PMID: 26394192
    8. Our data first time identified miR-186 as the upstream regulator of NSBP1 PMID: 26290438
    9. High HMGN5 expression is associated with urothelial bladder cancer. PMID: 25796505
    10. HMGN5 is an oncogene and plays an important role in prostate cancer tumorigenesis and progression. the level of HMGN5 may be used as a biomarker to predict the patients that would benefit from gemcitabine treatment. PMID: 25572120
    11. HMGN5 plays an oncogenic role in human breast cancer by inhibiting cell proliferation and invasion, and activating apoptosis, which could be exploited as a target for therapy in human breast cancer. PMID: 25315189
    12. HMGN5 knockdown sensitizes prostate cancer cells to ionizing radiation PMID: 25307178
    13. HMGN5 plays oncogenic role in osteosarcoma by promoting cell proliferation and invasion, and could be exploited as a target for therapy in osteosarcoma. PMID: 24687550
    14. HMGN5 is a critical factor in the development of chemoresistance through regulating autophagy, and it offers a novel target for improving osteosarcoma therapy. PMID: 24664583
    15. Data indicate that cells lacking either high mobility group protein N5 (HMGN5) and lamina-associated polypeptide 2alpha (LAP2alpha) showed that loss of either protein affects the genome-wide distribution of the remaining partner. PMID: 23673662
    16. HMGN5 silencing to significantly inhibit A549 and H1299 cell proliferation. PMID: 22994738
    17. HMGN5 may be a potential molecular target with therapeutic relevance for the treatment of prostate cancer. PMID: 22504871
    18. NSBP1 plays oncogenic role in clear cell renal cell carcinoma (ccRCC) by promoting cell proliferation and invasion. PMID: 22420896
    19. The data of study suggested that HMGN5 may play a critical role in the development of gliomas. PMID: 21373965
    20. these results suggest that NSBP1 promotes the viability of bladder cancer cells through increased cell proliferation PMID: 21695596
    21. HMGN5 has a highly disordered structure, binds dynamically to nucleosome core particles, modulates the binding of H1 to chromatin, reduces the compaction of the chromatin fiber, and affects transcription. PMID: 21518955
    22. A positive correlation was observed between NSBP1 expression and cell proliferation and apoptosis in DU145 cells. PMID: 20531280
    23. The structure of the HMGN5 gene and the known properties of the HMGN5 protein, are described. PMID: 20123071

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    HMGN family
  • 组织特异性：
    Ubiquitously expressed.
  • 数据库链接：

    HGNC: 8013

    OMIM: 300385

    KEGG: hsa:79366

    STRING: 9606.ENSP00000350848

    UniGene: Hs.282204