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HMHA1 Antibody

  • 货号：
    CSB-PA010579GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q92619
  • 基因名：
    ARHGAP45
  • 别名：
    HLA HA1 antibody; hmha1 antibody; HMHA1_HUMAN antibody; KIAA0223 antibody; mHag HA-1 antibody; Minor histocompatibility antigen HA 1 antibody; Minor histocompatibility antigen HA-1 antibody; Minor histocompatibility protein HA 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human HMHA1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Contains a GTPase activator for the Rho-type GTPases (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spreading. However, also contains N-terminally a BAR-domin which is able to play an autoinhibitory effect on this RhoGAP activity.; Precursor of the histocompatibility antigen HA-1. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. Specifically, mismatching for mHag HA-1 which is recognized as immunodominant, is shown to be associated with the development of severe GVHD after HLA-identical BMT. HA-1 is presented to the cell surface by MHC class I HLA-A*0201, but also by other HLA-A alleles. This complex specifically elicits donor-cytotoxic T-lymphocyte (CTL) reactivity against hematologic malignancies after treatment by HLA-identical allogenic BMT. It induces cell recognition and lysis by CTL.
  • 基因功能参考文献：
    1. ArhGAP45 acts as a Rac-GAP contributing to the balance between formation and disruption of endothelial junctions, which is required for the dynamic regulation of vascular permeability. PMID: 29174013
    2. HMHA1 significantly promotes melanoma cells proliferation, invasion and migration, and prevents cell apoptosis. PMID: 28939173
    3. Placental HA-1 expression is regulated by oxygen and is increased in the syncytial nuclear aggregates and syncytiotrophoblast of preeclamptic as compared to control placentas. PMID: 26095815
    4. study shows that HMHA1 acts as a RhoGAP to regulate GTPase activity, cytoskeletal remodeling and cell spreading, which are crucial functions in normal hematopoietic and cancer cells PMID: 24086303
    5. the information on allele and genotype frequencies of HA-1 and HA-2 in a Taiwanese population PMID: 20509834
    6. The intensity of the tetramer-staining of the HA-1/HA-2-specific cytotoxic T cells strongly correlates with their capability to recognize mHag positive target cells. PMID: 11920221
    7. HA-1-specific CTLs restricted by nonself HLA-A2 molecules can be generated in an HLA-A2-mismatched setting. PMID: 12091347
    8. In bone marrow transplant recipients and their genetically HLA-identical siblings, the presence of different alleles of two minor histocompatibility antigen genes is studied. PMID: 15350465
    9. Pre-existing HA-1-specific T cells are observed in cord blood samples. Both circulating and ex vivo-generated HA-1-specific T cells show specific and hematopoietic restricted lysis of HLA-A2+/HA-1+ target cells, including leukemic cells. PMID: 15498856
    10. the incidence of the HA-1 168His allele is significantly lower in Sjogren's syndrome patients than in controls PMID: 15593299
    11. There was no difference in acute rejection rates between the HA-1-matched and -mismatched groups in kidney transplantation. PMID: 17580157
    12. targeting mHags encoded not only by HMHA1, whose aberrant expression in solid tumors has been reported, but also BCL2A1 may bring about beneficial selective graft-versus-tumor effects PMID: 18414982
    13. study examined antigenic presentation & T-cell recognition of HA-1, a prototypic autosomal mHag derived from single nucleotide dimorphism (HA-1(H) versus HA-1(R)) in the HMHA1 gene; results define the molecular mechanisms governing immunogenicity of HA-1 PMID: 19234124

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  • 亚细胞定位：
    Cytoplasm. Cell projection, ruffle membrane.
  • 组织特异性：
    Expressed on cells of the hematopoietic lineage. Detected in dendritic cells and epidermal Langerhans cells. Expressed in peripheral blood mononuclear cells, in all leukemia/lymphoma cell lines. Detected also in some solid tumors and tissues such as cance
  • 数据库链接：

    HGNC: 17102

    OMIM: 601155

    KEGG: hsa:23526

    STRING: 9606.ENSP00000316772

    UniGene: Hs.465521