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HNRNPF Antibody

  • 货号：
    CSB-PA571130
  • 规格：
    ￥2024
  • 图片：
    • Western blot analysis of extracts from HepG2 cells, using hnRNP F antibody.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) HNRNPF Polyclonal antibody
  • Uniprot No.：
    P52597
  • 基因名：
    HNRNPF
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from N-terminal of Human hnRNP F.
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state.
  • 基因功能参考文献：
    1. hnRNP H/F are important for maintenance and differentiation of embryonic stem cells and that this at least in part reflects a switch in TCF3 alternative splicing that leads to repression of CDH1/E-cadherin. PMID: 30115631
    2. Results from a study on gene expression variability markers in early-stage human embryos shows that HNRNPF is a putative marker for the 3-day, 8-cell embryo stage. PMID: 26288249
    3. heterogeneous nuclear ribonucleoprotein F (hnRNPF) regulates G-quadruplex-associated alternative splicing across the transcriptome. PMID: 29269483
    4. Simulation results demonstrate that the RNA binding domain qRRM2 of hnRNP F binds strongly with G-tract RNA, but any mutation of the G-tract leads to a drastic reduction of the binding free energy. PMID: 29050934
    5. Human T2D kidneys exhibited more RPTC apoptosis and lower expression of hnRNP F, SIRTUIN-1, and FOXO3alpha than nondiabetic kidneys. PMID: 28424160
    6. hnRNP F is a co-factor in a subset of tristetraprolin/BRF1/BRF2-mediated mRNA decay. PMID: 24978456
    7. this result suggests that hnRNP F directs formation of the exon 4 minus variant of ENOX2. PMID: 21625959
    8. The study shows solution structures of the three quasi-RNA-recognition motifs of heterogeneous nuclear ribonucleoprotein F in complex with G-tract RNA. PMID: 20526337
    9. heterogeneous ribonucleoprotein F is involved in the regulation of cell proliferation via the mammalian target of rapamycin/S6 kinase 2 pathway PMID: 20308064
    10. Results suggest that hnRNP H and F are nuclear shuttling proteins whose posttranslational modifications may alter interaction with transportin 1, nuclear localization, and hence function. PMID: 20308327
    11. high levels of hnRNP F are present in premalignant and malignant stages of colorectal cancer, reflecting a role for this protein early in colorectal tumorigenesis PMID: 16424007
    12. The solution structure of the three quasi RNA recognition motifs of hnRNP F and identification of the residues that are important for the interaction with the Bcl-x RNA. PMID: 16885237
    13. hnRNPH and F regulate DM20 splicing by recruiting U1snRNP and hnRNPH plays a primary role in DM20 splice site selection in vivo PMID: 19244236
    14. Shows that hnRNPF regulates the 3' end cleavage reaction. PMID: 11158309

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  • 亚细胞定位：
    Nucleus, nucleoplasm.
  • 组织特异性：
    Expressed ubiquitously.
  • 数据库链接：

    HGNC: 5039

    OMIM: 601037

    KEGG: hsa:3185

    STRING: 9606.ENSP00000338477

    UniGene: Hs.712955