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HOMER2 Antibody

  • 货号：
    CSB-PA123223
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA123223(HOMER2 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA123223(HOMER2 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q9NSB8
  • 基因名：
  • 别名：
    HOMER2 antibody; Homer protein homolog 2 antibody; Homer-2 antibody; Cupidin antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Fusion protein of Human HOMER2
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses. Required for normal hearing. Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA.
  • 基因功能参考文献：
    1. that HOMER2 may be involved in tumourigenesis of endometrioid uterine tumours PMID: 29891190
    2. Homer1 and Homer2 might be considered as novel diagnostic biomarkers for large-artery atherosclerosis stroke. PMID: 27832625
    3. This study showed that HOMER2 (rs1256429; intronic, p = 8.7 x 10(1)) associated with Alzheimer disease. PMID: 25649652
    4. These data provide compelling evidence that HOMER2 is required for normal hearing and that its sequence alteration in humans leads to ADNSHL through a dominant-negative mode of action PMID: 25816005
    5. monitored Homer1 and Homer2 expression and subcellular localization in skeletal muscle biopsies following 60 days of bedrest PMID: 21885651
    6. Haplotypes of the HOMER 1 and 2 genes are unlikely to play a major role in the pathophysiology of alcohol dependence. PMID: 20333726
    7. This study supports a role for HOMER2 gene in schizophrenia susceptibility. PMID: 19914345
    8. Polymorphism in the Homer2 gene is not a potential risk factor for the development of cocaine dependence in an African American population. PMID: 16314758

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  • 相关疾病：
    Deafness, autosomal dominant, 68 (DFNA68)
  • 亚细胞定位：
    Cytoplasm. Cell membrane. Cell junction, synapse, postsynaptic density. Cell junction, synapse. Cell projection, stereocilium. Note=Postsynaptic density of neuronal cells. The stabilization and clustering of the metabotropic glutamate receptors appears to be mediated by isoform 1 and isoform 2 at the cell surface.
  • 蛋白家族：
    Homer family
  • 数据库链接：

    HGNC: 17513

    OMIM: 604799

    KEGG: hsa:9455

    STRING: 9606.ENSP00000305632

    UniGene: Hs.578443