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HORMAD1 Antibody

  • 货号：
    CSB-PA803140LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) HORMAD1 Polyclonal antibody
  • Uniprot No.：
    Q86X24
  • 基因名：
    HORMAD1
  • 别名：
    HORMAD1 antibody; NOHMA antibody; HORMA domain-containing protein 1 antibody; Cancer/testis antigen 46 antibody; CT46 antibody; Newborn ovary HORMA protein antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human HORMA domain-containing protein 1 protein (201-394AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，HORMAD1 Antibody (CSB-PA803140LA01HU)，的标记方式是Non-conjugated。对于HORMAD1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA803140LB01HU HORMAD1 Antibody, HRP conjugated ELISA
    FITC CSB-PA803140LC01HU HORMAD1 Antibody, FITC conjugated
    Biotin CSB-PA803140LD01HU HORMAD1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single-stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes.
  • 基因功能参考文献：
    1. Genomic Complexity Profiling Reveals That HORMAD1 Overexpression Contributes to Homologous Recombination Deficiency in Triple-Negative Breast Cancers PMID: 25770156
    2. Hormad1 and Hormad2 might not be the susceptible genes for the non-obstructive azoospermia in our study population. However, rs718772 of Hormad2 variant might be associated with testis development in NOA patients. PMID: 24803422
    3. HORMAD1 gene silencing resulted in significantly reduced VEGF protein levels and microvessel density compared to controls in epithelial ovarian carcinoma. PMID: 22776561
    4. This is the first report showing that HORMAD1 single-nucleotide polymorphisms (SNPs) may predispose men to a defect in spermatogenesis, although the causal and potential mechanistic relationships between these HORMAD1 SNPs and azoospermia remain unclear. PMID: 22407170
  • 亚细胞定位：
    Nucleus. Chromosome.
  • 组织特异性：
    Testis-specific. Over-expressed in carcinomas.
  • 数据库链接：

    HGNC: 25245

    OMIM: 609824

    KEGG: hsa:84072

    STRING: 9606.ENSP00000355167

    UniGene: Hs.298312