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HOXA11 Antibody

  • 货号：
    CSB-PA010649LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA010649LA01HU diluted at 1:100 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescence staining of PC-3 cells with CSB-PA010649LA01HU at 1:33, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) HOXA11 Polyclonal antibody
  • Uniprot No.：
    P31270
  • 基因名：
    HOXA11
  • 别名：
    Homeo box 1I antibody; Homeo box A11 antibody; Homeobox A11 antibody; Homeobox protein Hox A11 antibody; Homeobox protein Hox-1I antibody; Homeobox protein Hox-A11 antibody; Homeobox protein HOXA11 antibody; Hox 1I antibody; HOX1 antibody; HOX1I antibody; HOXA11 antibody; HXA11_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Homeobox protein Hox-A11 protein (115-176AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，HOXA11 Antibody (CSB-PA010649LA01HU)，的标记方式是Non-conjugated。对于HOXA11 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA010649LB01HU HOXA11 Antibody, HRP conjugated ELISA
    FITC CSB-PA010649LC01HU HOXA11 Antibody, FITC conjugated
    Biotin CSB-PA010649LD01HU HOXA11 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
  • 基因功能参考文献：
    1. we uncovered a novel potential regulatory mechanism between HOTTIP and one of its physical HOXA clusters, HOXA11. Hence, HOTTIP may mediate, at least partly, HOXA11 expression involved in cell growth, migration, and apoptosis of breast cancer MCF-7 cells. PMID: 29415429
    2. High expression of lncRNA HOXA11-AS promotes breast cancer invasion and metastasis by affecting EMT. PMID: 28701685
    3. HOXA11 silencing suppressed osteosarcoma cell proliferation, invasion and induced cell arrest. PMID: 28558357
    4. Results show that aberrant hypermethylation and the methylation-induced down-regulation of HOXA11 may promote lung adenocarcinoma progression. PMID: 28380439
    5. Hypermethylation of HOXA11 is an independent prognostic biomarker in breast cancer. Suggest HOXA11 as a potential tumor suppressor. PMID: 28038461
    6. The treatment resistance induced by the underexpression of HOXA11 can contribute to a poor prognosis in GBM. PMID: 27456940
    7. These results suggest that mutations in the coding sequence of HOXA11 might not be a common cause of cryptorchidism, while common polymorphisms in the HOXA11 gene might contribute to the risk of developing unilateral cryptorchidism. PMID: 28261830
    8. demonstrated that HOXA11-antisense(AS) functioned as a molecular sponge for miR-124, and overexpression of miR-124 attenuated the proliferation and invasion-promoting effect of HOXA11-AS PMID: 28749709
    9. Bioinformatics prediction forecast that miR-140-5p directly targeted HOXA11-antisense RNA at 3'-UTR, which was confirmed by luciferase reporter assay PMID: 28832185
    10. HOXA11-AS functions as a competing endogenous RNA. PMID: 29034803
    11. our study demonstrated that HOXA11 function as a tumor suppressor in renal cell carcinoma PMID: 28423531
    12. Laparoscopic endometrioma resection increases peri-implantation endometrial HOXA-11 mRNA expression. PMID: 26056923
    13. Epigenetic silencing of HOXA11 promotes gastric cancer proliferation, migration and invasion through activation of Wnt signaling. PMID: 25590359
    14. The overexpression of miR-30d or 181a suppressed HOXA11 mRNA. PMID: 25630974
    15. Low HOXA11 expression is associated with hepatocellular carcinoma. PMID: 24306662
    16. Mutations in the coding region of HOXA11 are not common in Chinese women with Mullerian duct anomalies. PMID: 24745830
    17. Study suggests that HOXA11 hypermethylation may contribute to the progression of NSCLC by promoting cell proliferation or migration. PMID: 24259349
    18. Lower expression of HOXA11 is associated with endometriosis-associated infertility. PMID: 23979130
    19. Promoter methylation of HOXA11 is associated with glioblastoma. PMID: 23624749
    20. reduced HOXA11 expression may contribute to endometriosis-associated infertility PMID: 22233680
    21. Endometrial HOXA11 and LIF mRNA expression levels (normalized to beta-actin expression) were significantly decreased in endometrium of infertile patients with endometriosis compared with healthy fertile controls PMID: 21987111
    22. The result suggest that HOXA-11 gene expression in the endometrium during the implantation window may not be altered in patients with idiopathic infertility. PMID: 21526497
    23. Expression of HOXA11 represses the expression of p53 in uterosacral ligaments. PMID: 19372592
    24. Our results suggest that altered HOXA11 gene expression in the endometrium during a menstrual cycle may be a common phenomenon among patients with endometriosis and may cause infertility in this group of patients PMID: 20695189
    25. NUP98 primer and a degenerate primer corresponding to the third helix of the homeodomain of HOXA demonstrated that NUP98 was fused in-frame to HOXA11 in the patient with CML ( chronic myelogenous leukemia) PMID: 11830496
    26. expressed in the developing kidney PMID: 12060755
    27. HOXA gene expression is up-regulated at the ectopic implantation site in the fallopian tube and it may play a role in ectopic pregnancies. PMID: 15167850
    28. study reveals a novel expression pattern for homeo box A11(HOXA11) gene in human endometrium PMID: 15467538
    29. The HOXA11 gene cluster is in T-cell malignancies resulting in deregulated HOXA gene expression and is in keeping with a previous report suggesting HOXA deregulation in MLL-rearranged T cell lymphoblastic leukemia. PMID: 15674412
    30. HOXA11 is critical for development and maintenance of uterosacral ligaments and deficient in pelvic prolapse. PMID: 18274672
    31. Our findings do not support the hypothesis that mutations in the HOXA11 coding regions are involved in the pathogenesis of human non-syndromal congenital renal parenchymal malformations. PMID: 19255789
    32. Methylation of HOXA11 gene is associated with high-grade squamous intraepithelial lesions in cervical cancer PMID: 19609949

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  • 相关疾病：
    Radioulnar synostosis with amegakaryocytic thrombocytopenia 1 (RUSAT1)
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Abd-B homeobox family
  • 数据库链接：

    HGNC: 5101

    OMIM: 142958

    KEGG: hsa:3207

    STRING: 9606.ENSP00000006015

    UniGene: Hs.249171