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HOXA2 Antibody

  • 货号：
    CSB-PA010652LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA010652LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA010652LA01HU at dilution of 1:100
    • Western Blot
      Positive WB detected in: Jurkat whole cell lysate, Mouse liver tissue, Mouse kidney tissue, Mouse stomach tissue
      All lanes: Hoxa2 antibody at 2μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 42 kDa
      Observed band size: 42 kDa
  • 其他：

产品详情

  • 产品描述：
    HOXA2 polyclonal antibody CSB-PA010652LA01HU was produced in rabbit immunized by using the Recombinant Human Homeobox protein Hox-A2 protein (26-124AA) as the immunogen. The target protein HOXA2 is sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Diseases associated with HOXA2 include Microtia, Hearing Impairment, and Cleft Palate and Microtia.
    This Rabbit anti-Homo sapiens (Human) HOXA2 Polyclonal antibody was tested in the ELISA, WB and IHC. The non-conjugated IgG got purified by protein G and reached up to 95% in purity. It reacts with the HOXA2 proteins of human or mouse-origin and may be used to detect the endogenous levels of HOXA2 protein.
  • 产品名称：
    Rabbit anti-Homo sapiens (Human) HOXA2 Polyclonal antibody
  • Uniprot No.：
    O43364
  • 基因名：
    HOXA2
  • 别名：
    AI324701 antibody; homeo box A2 antibody; homeobox A2 antibody; Homeobox protein Hox-1K antibody; Homeobox protein Hox-A2 antibody; Hox-1.11 antibody; HOX1.11 antibody; HOX1K antibody; Hoxa-2 antibody; Hoxa11 antibody; HOXA2 antibody; HXA2_HUMAN antibody; MGC151482 antibody; MGC151484 antibody; RATHOX111A antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Homeobox protein Hox-A2 protein (26-124AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，HOXA2 Antibody (CSB-PA010652LA01HU)，的标记方式是Non-conjugated。对于HOXA2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA010652LB01HU HOXA2 Antibody, HRP conjugated ELISA
    FITC CSB-PA010652LC01HU HOXA2 Antibody, FITC conjugated
    Biotin CSB-PA010652LD01HU HOXA2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:2000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
  • 基因功能参考文献：
    1. Performed mutational analysis of TCOF1, GSC, and HOXA2 to determine the mutational features of the 3 genes in Chinese patients with Treacher Collins syndrome. PMID: 27526242
    2. The role of HOXA2 gene in dominant isolated microtia and the dysmorphogenetic effect of this gene on ear development PMID: 27503514
    3. 5 genomic variants in GSC, HOXA2 and PRKRA were identified through mutational analysis in Chinese patients with microtia. PMID: 28109504
    4. The Hoxa2-mediated decay of RCHY1 involves both the 19S and 20S proteasome complexes PMID: 26496426
    5. HOXA2 acts as a suppressor or TBP-antagonist to inhibit MMP-9 expression; while methylation-mediated inactivation of HOXA2 in NPC derepresses MMP-9 production and increases invasion of NPC cells. PMID: 24243817
    6. we have identified a nonsense mutation (Q235*) in HOXA2 that segregates with bilateral nonsyndromic microtia and hearing loss through three generations of a family in an autosomal dominant pattern. PMID: 23775976
    7. Lack of mutations in the coding region of HOXA2 among the sporadic microtia patients. PMID: 20542577
    8. A missense mutation in the HOXA2 in a consanguineous iranian family with bilateral microtia was reported. PMID: 18394579

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  • 相关疾病：
    Microtia, hearing impairment, and cleft palate (MHICP); Microtia with or without hearing impairment (MCRT)
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Antp homeobox family, Proboscipedia subfamily
  • 数据库链接：

    HGNC: 5103

    OMIM: 604685

    KEGG: hsa:3199

    STRING: 9606.ENSP00000222718

    UniGene: Hs.445239