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HOXA4 Antibody

  • 货号：
    CSB-PA010654LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Rat kidney tissue
      All lanes: HOXA4 antibody at 2.3μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 35 kDa
      Observed band size: 35 kDa
    • IHC image of CSB-PA010654LA01HU diluted at 1:800 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) HOXA4 Polyclonal antibody
  • Uniprot No.：
    Q00056
  • 基因名：
    HOXA4
  • 别名：
    Dfd like protein antibody; Homeo box A4 antibody; Homeobox A4 antibody; Homeobox protein Hox-1.4 antibody; Homeobox protein Hox-1D antibody; Homeobox protein Hox-A4 antibody; Hox 1.4 like protein antibody; hox-1.4 antibody; hox-1d antibody; HOX1 antibody; HOX1D antibody; HOXA4 antibody; HXA4_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Rat
  • 免疫原：
    Recombinant Human Homeobox protein Hox-A4 protein (23-173AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，HOXA4 Antibody (CSB-PA010654LA01HU)，的标记方式是Non-conjugated。对于HOXA4 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA010654LB01HU HOXA4 Antibody, HRP conjugated ELISA
    FITC CSB-PA010654LC01HU HOXA4 Antibody, FITC conjugated
    Biotin CSB-PA010654LD01HU HOXA4 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:500-1:1000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to sites in the 5'-flanking sequence of its coding region with various affinities. The consensus sequences of the high and low affinity binding sites are 5'-TAATGA[CG]-3' and 5'-CTAATTTT-3'.
  • 基因功能参考文献：
    1. HOXA4/HOXB3 gene expression-based risk score may be useful for prognostic risk stratification and warrants prospective validation in HGSOC patients. PMID: 29402501
    2. Overexpression of HOXA4 and HOXA9 contributes to self-renewal and overpopulation of stem cells in colorectal cancers. PMID: 28464221
    3. HOXA4 increases short-term repopulation to higher levels than HOXB4, which may involve Notch signaling to induce self-renewal of primitive hematopoietic cells PMID: 26166023
    4. The NK AML patients with NPM1 mutations exhibited elevated HOXA4 methylation and expression levels of HOXA5 and MEIS1 compared with the NPM1 wildtype patients. PMID: 25585874
    5. promoter hypermethylation of HOXA4 gene could be an epigenetic mechanism mediating IM resistance in CML patients. PMID: 23484077
    6. HOXA4 showed nuclear & perinuclear staining in endothelial & smooth muscle cells in aorta. Spatial variation in expression in human aortas persisted into adulthood. Downregulation of HOXA4 expression was associated with abdominal aortic aneurysm. PMID: 21627813
    7. Studies suggest that HOXA4, HOXA5 and HOXB4 provide the spatial information needed to restrict the response to signals from the notochord, and not up regulated in pancreatic cancer. PMID: 21546695
    8. Results confirm that HOXA4 inhibits cell motility, show that it suppresses cell spreading and filopodia formation while enhancing cell-cell adhesion, and suggest a role for beta1 integrin in mediating these changes. PMID: 19723874
    9. upregulated significantly in acute myeloid leukemia patients with a white blood cell count higher than 30 x 10(9)/L cells. PMID: 12031912
    10. aberrant DNA methylation may have a major role in the control of HOXA4 gene expression in chronic lymphocytic leukemia PMID: 16688227
    11. analysis of the role of deregulated PcG genes in acute myeloid leukemia, and the downstream PcG targets HOXA4, HOXA9 and MEIS1 PMID: 18410541
    12. combination of low HOXA4 and low MEIS1 gene expression is a favourable predictor for outcome in all AML patients and that the expression levels are governed by the methylation state of these genes. PMID: 19563517

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Antp homeobox family, Deformed subfamily
  • 组织特异性：
    Embryonic nervous system.
  • 数据库链接：

    HGNC: 5105

    OMIM: 142953

    KEGG: hsa:3201

    STRING: 9606.ENSP00000353151

    UniGene: Hs.533357