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HOXA7 Antibody

  • 中文名称：
    HOXA7兔多克隆抗体
  • 货号：
    CSB-PA002957
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of Jurkat cells using Hox-A7 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    P31268
  • 基因名：
    HOXA7
  • 别名：
    ANTP antibody; Antp, Drosophila, homolog of antibody; Homeobox 1A antibody; Homeobox A7 antibody; Homeobox protein Hox 1.1 antibody; Homeobox protein Hox A7 antibody; Homeobox protein Hox-1A antibody; Homeobox protein Hox-A7 antibody; HOX1 antibody; HOX1.1 antibody; HOX1.1, mouse, homolog of antibody; Hox1A antibody; HOXA7 antibody; HXA7_HUMAN antibody; OTTHUMP00000024835 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human Hox-A7.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
  • 基因功能参考文献：
    1. Silencing of HOTAIR and HOXA7 could effectively inhibit tumor growth and increase chemosensitivity of ovarian tumors in nude mice. PMID: 29455183
    2. data suggest that HOXA7 could serve as a diagnostic marker for OSCC or a treatment target PMID: 28529281
    3. Results showed that HOXA7 was highly expressed in liver cancer cells which related with poorer prognosis. Its overexpression significantly promoted invasion and metastasis of liver cancer cells by activating Snail expression. PMID: 27600149
    4. The homeodomain and N- and C-termini are critical to transcriptional activation by Hoxa1 protein. The N-terminus also modulates interaction with Pbx1a protein during DNA-binding. PMID: 20336696
    5. HOXA7 might be a new gene candidate that influences the maturation of acute myeloid leukemia. PMID: 26828989
    6. HOXA7 promotes cell proliferation, and these changes were mediated by cyclin E1/CDK2 PMID: 25501982
    7. variants in the HOXA7 and HOXA9 genes are not common in Chinese women with Mullerian duct abnormalities PMID: 25246116
    8. This finding contributes to our understanding of the role HOXA7 plays in regulating the proliferation of ER-positive cancer cells. PMID: 24099775
    9. Hoxa7, Hoxa9 and Hox cofactor Meis1 were identified as AP-2alpha target genes, which are involved in myeloid leukemogenesis. PMID: 23660297
    10. Data show that up-regulation of the HOXA7, HOXA9, HOXA11, and PBX3 resulting from the down-regulation of miR-181 family members probably contribute to the poor prognosis of patients with nonfavorable cytogenetically abnormal AML (CA-AML). PMID: 22251480
    11. found evidence for association of bone geometry variation with an SNP in ENPP1, a gene in the mineralization pathway. The alteration of a binding site of the deregulator of extracellular matrix HOXA7 warrants further investigation PMID: 19888898
    12. Taken together, these results support the notion that down-regulation of PCGF2 is sufficient to induce granulocytic differentiation of HL-60 cells via de-repression of HOXA7 gene expression. PMID: 22085718
    13. Several targets of MLL fusions, MEIS1, HOXA7, HOXA9, and HOXA10 are functionally related and have been implicated in leukemias. Each of the four genes was knocked down separately in the precursor B-cell leukemic line RS4;11 expressing MLL-AF4. PMID: 21518888
    14. HOXA7, PIXT1 and PRRX1 homeobox genes have different patterns of expression in oral squamous cell carcinomas depending on its histological features. PMID: 21323949
    15. A novel mechanistic role for HOXA7 in modulating granulosa cell proliferation via upregulation of EGFR. PMID: 20540809
    16. B-lineage development can proceed in t(4;11) leukemic blasts in the absence of HOX-A gene expression. PMID: 14562113
    17. Hox A7-sustained expression disturbs the regulation of cell adhesive and migratory capacities on fibronectin during early differentiation. PMID: 14704364
    18. Study reveals the preferential expression of HOXA7 by germinal vesicle (GV) oocytes. PMID: 16597639
    19. HOXA7 staining of tumor cell nuclei is correlated significantly with improved disease-specific survival, which is suggestive of the biological and potentially clinical importance of subcellular HOXA7 localization. PMID: 17959889

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Antp homeobox family
  • 数据库链接：

    HGNC: 5108

    OMIM: 142950

    KEGG: hsa:3204

    STRING: 9606.ENSP00000242159

    UniGene: Hs.610216