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HOXB1 Antibody

  • 货号：
    CSB-PA010660GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    P14653
  • 基因名：
  • 别名：
    HCFP3 antibody; Homeo box 2I antibody; Homeo box B1 antibody; Homeobox 2I antibody; Homeobox B1 antibody; Homeobox protein Hox B1 antibody; Homeobox protein Hox-2I antibody; Homeobox protein Hox-B1 antibody; Homeobox protein HoxB1 antibody; Homeobox2I antibody; HomeoboxB1 antibody; HOX 2 antibody; Hox 2.9 antibody; HOX 2I antibody; HOX B1 antibody; HOX2 antibody; Hox2.9 antibody; HOX2I antibody; HOXB 1 antibody; HOXB1 antibody; HOXB1 protein antibody; HXB1_HUMAN antibody; MGC116843 antibody; MGC116844 antibody; MGC116845 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Human HOXB1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures.
  • 基因功能参考文献：
    1. This is the first disease-associated HOXB1 mutation with a likely loss-of-function effect suggesting that all HOXB1 variants reported so far also have severe impact on activity of this transcriptional regulator PMID: 27144914
    2. findings revealed a novel homozygous mutation p.Arg230Trp (c.688C>T) within the HOXB1 gene of three members of a Turkish family with hereditary congenital facial paresis (HCFP3) PMID: 27640920
    3. HOXB1 functions as a tumor suppressor, regulated by miR-3175 in glioma. PMID: 26565624
    4. The resulting phenotype includes bilateral facial palsy, hearing loss, and strabismus and correlates extensively with the previously reported Hoxb1(-/-) mouse phenotype. PMID: 22770981
    5. Hoxb1 Expression Induces Cell Fate Changes in the Trunk Neural Tube. PMID: 21433221
    6. analysis of a tethered-hopping model for protein-DNA binding and unbinding based on Sox2-Oct1-Hoxb1 ternary complex simulations PMID: 20371328
    7. Data show that inducible Hox genes are selectively sensitive to the inhibition of actin polymerization and that actin polymerization is required for the assembly of a transcription complex on the regulatory region of the Hox genes. PMID: 19477923
    8. It is unlikely that HoxB1 plays a significant role in the genetic predisposition to autism. PMID: 11840501
    9. UTX directly binds to the HOXB1 locus and is required for its activation PMID: 17713478
    10. HoxB1 interacts with Pax6 and enhances its transcriptional activity. This interaction was modeled on a demonstrated interaction between zebrafish Pax6 and human HoxB1. PMID: 11069920

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  • 相关疾病：
    Facial paresis, hereditary congenital, 3 (HCFP3)
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Antp homeobox family, Labial subfamily
  • 数据库链接：

    HGNC: 5111

    OMIM: 142968

    KEGG: hsa:3211

    STRING: 9606.ENSP00000355140

    UniGene: Hs.99992