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HOXD3 Antibody

  • 货号：
    CSB-PA010686GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    P31249
  • 基因名：
    HOXD3
  • 别名：
    Homeo box D3 antibody; Homeobox D3 antibody; Homeobox protein Hox D3 antibody; Homeobox protein Hox-4A antibody; Homeobox protein Hox-D3 antibody; Homeobox protein HoxD3 antibody; Homeodomain protein antibody; HOX 1D antibody; HOX 4 antibody; Hox 4.1 antibody; Hox 4A antibody; HOX D3 antibody; Hox-4.1 mouse homolog of antibody; HOX1D antibody; HOX4 antibody; Hox4.1 antibody; HOX4A antibody; HOXD 3 antibody; HOXD3 antibody; HXD3_HUMAN antibody; MGC10470 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human HOXD3
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
  • 基因功能参考文献：
    1. The findings indicate that miR-203a inhibits hepatocellular carcinoma cell invasion, metastasis, and angiogenesis by negatively targeting HOXD3 and suppressing cell signaling through the VEGFR pathway. PMID: 29402992
    2. EGR1 is a key player in the transcriptional control of miR-203a, and that miR-203a acts as an anti-oncogene to suppress HCC tumorigenesis by targeting HOXD3 through EGFR-related cell signaling pathways. PMID: 27244890
    3. the HOXD3 gene promotes colorectal cancer cell growth and plays a pivotal role in the development and survival of malignant human colorectal cancer cells. PMID: 27499213
    4. These results validate the association between promoter hypermethylation of ABHD9 and HOXD3 and prostate cancer recurrence PMID: 24718283
    5. HOXD3 promoter hypermethylation is correlated with clinicopathologic features in prostate cancer. This correlation is more common in older, higher risk patients. PMID: 24847526
    6. High expression of HOXD3 correlates with invasive breast cancer. PMID: 22935821
    7. quantitative increase in promoter methylation levels of HOXD3 is associated with prostate cancer progression PMID: 21207416
    8. HOXD3 methylation distinguishes low-grade prostate cancers from intermediate and high-grade ones. PMID: 20212450
    9. transduction of antisense DNA into human melanoma cells results in decreased invasive and motile activities PMID: 12405287
    10. Hox D3 coordinately regulates the expression of integrin alpha5beta1 and integrin alphavbeta3 during angiogenesis in vivo. PMID: 14610084
    11. HoxD3 may provide a means to directly improve collagen deposition, angiogenesis and closure in poorly healing diabetic wounds. PMID: 14633614
    12. HOXD3 may play an important role in regulating cerebral angiogenesis, and that gene transfer of HOXD3 may provide a novel and potent means to stimulate angiogenesis PMID: 15545924
    13. The karyotype of our patient suggests another possible locus of the Duane syndrome, and the mapped genes around the deleted region, 1q42.13-43, contain possible candidate genes such as a homeobox gene. PMID: 17126050
    14. Further validation of candidate genes on a separate cohort of low and high grade prostate cancers by quantitative MethyLight analysis has allowed us to confirm DNA hypermethylation of HOXD3 and BMP7... PMID: 19283074

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Antp homeobox family
  • 数据库链接：

    HGNC: 5137

    OMIM: 142980

    KEGG: hsa:3232

    STRING: 9606.ENSP00000249440

    UniGene: Hs.93574