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HRSP12 Antibody

  • 货号：
    CSB-PA010744GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    P52758
  • 基因名：
    RIDA
  • 别名：
    14.5 kDa translational inhibitor protein antibody; 2-iminobutanoate/2-iminopropanoate deaminase antibody; Heat responsive protein 12 antibody; Heat-responsive protein 12 antibody; Hrsp12 antibody; p14.5 antibody; Perchloric acid soluble protein antibody; PSP antibody; Reactive intermediate imine deaminase A homolog antibody; Ribonuclease UK114 antibody; RIDA antibody; Translational inhibitor p14.5 antibody; Translational inhibitor protein p14.5 antibody; UK114 antibody; UK114 antigen homolog antibody; UK114_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human HRSP12
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase.; Also promotes endoribonucleolytic cleavage of some transcripts by promoting recruitment of the ribonuclease P/MRP complex. Acts by bridging YTHDF2 and the ribonuclease P/MRP complex. RIDA/HRSP12 binds to N6-methyladenosine (m6A)-containing mRNAs containing a 5'-GGUUC-3' motif: cooperative binding of RIDA/HRSP12 and YTHDF2 to such transcripts lead to recruitment of the ribonuclease P/MRP complex and subsequent endoribonucleolytic cleavage.
  • 基因功能参考文献：
    1. x-ray crystallography study of p14.5 PMID: 14997576
    2. analysis of ligand binding sites of protein p14.5 PMID: 16198412
  • 亚细胞定位：
    Cytoplasm. Nucleus. Peroxisome. Mitochondrion.
  • 蛋白家族：
    RutC family
  • 组织特异性：
    Expressed predominantly in liver and kidney. Lower levels in lung and brain.
  • 数据库链接：

    HGNC: 16897

    OMIM: 602487

    KEGG: hsa:10247

    STRING: 9606.ENSP00000254878

    UniGene: Hs.18426