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HSCB Antibody

  • 货号：
    CSB-PA816893LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: U87 whole cell lysate, Rat heart tissue, Rat liver tissue
      All lanes: HSCB antibody at 2.7µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 28 kDa
      Observed band size: 28 kDa
    • Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA816893LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) HSCB Polyclonal antibody
  • Uniprot No.：
    Q8IWL3
  • 基因名：
    HSCB
  • 别名：
    AI325508 antibody; AW049829 antibody; dJ366L4.2 antibody; DnaJ (Hsp40) homolog, subfamily C member 20 antibody; DnaJ homolog subfamily C member 20 antibody; DNAJC20 antibody; Hsc20 antibody; HSC20_HUMAN antibody; hscB antibody; HscB iron sulfur cluster co chaperone homolog antibody; Iron sulfur cluster co chaperone protein HscB mitochondrial antibody; Iron-sulfur cluster co-chaperone protein HscB antibody; J type co chaperone HSC20 antibody; JAC1 antibody; mitochondrial antibody; RGD1311005 antibody; RP3-366L4.2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Rat
  • 免疫原：
    Recombinant Human Iron-sulfur cluster co-chaperone protein HscB, mitochondrial protein (30-235AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，HSCB Antibody (CSB-PA816893LA01HU)，的标记方式是Non-conjugated。对于HSCB Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA816893LB01HU HSCB Antibody, HRP conjugated ELISA
    FITC CSB-PA816893LC01HU HSCB Antibody, FITC conjugated
    Biotin CSB-PA816893LD01HU HSCB Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acts as a co-chaperone in iron-sulfur cluster assembly in both mitochondria and the cytoplasm. Required for incorporation of iron-sulfur clusters into SDHB, the iron-sulfur protein subunit of succinate dehydrogenase that is involved in complex II of the mitochondrial electron transport chain. Recruited to SDHB by interaction with SDHAF1 which first binds SDHB and then recruits the iron-sulfur transfer complex formed by HSC20, HSPA9 and ISCU through direct binding to HSC20. Also mediates complex formation between components of the cytosolic iron-sulfur biogenesis pathway and the CIA targeting complex composed of CIAO1, DIPK1B/FAM69B and MMS19 by binding directly to the scaffold protein ISCU and to CIAO1. This facilitates iron-sulfur cluster insertion into a number of cytoplasmic and nuclear proteins including POLD1, ELP3, DPYD and PPAT.
  • 基因功能参考文献：
    1. Nfu is shown to bind to both chaperone proteins with binding affinities similar to those observed for IscU binding to the homologous HSPA9 and Hsc20, while Nfu can also stimulate the ATPase activity of HSPA9 PMID: 29211945
    2. The delivery of assembled Fe-S clusters to recipient proteins is a crucial step in the biogenesis of Fe-S proteins; review focuses on recent insights into the molecular mechanism of amino acid motif recognition and discrimination by the co-chaperone HSC20 and finds co-chaperone HSC20 binds to LYR motifs present in Fe-S recipient proteins or their binding partners. [Review] PMID: 27714045
    3. the crucial role of HSC20 in the assembly of the mitochondrial respiratory chain, is reported. PMID: 28380382
    4. NFS1 binds preferentially to the D-state of ISCU while mtHSP70 binds preferentially to the D-state of ISCU and HSC20 binds preferentially to the S-state of ISCU. PMID: 23940031
    5. A cysteine-rich N-terminal domain, which clearly distinguishes hHSC20 from the specialized DnaJ type III proteins of fungi and most bacteria, was found to be important for the integrity and function of the human co-chaperone. PMID: 20668094
    6. structural analysis of human J-type co-chaperone HscB reveals a tetracysteine metal-binding domain PMID: 18713742

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  • 亚细胞定位：
    [Iron-sulfur cluster co-chaperone protein HscB, cytoplasmic]: Cytoplasm.; [Iron-sulfur cluster co-chaperone protein HscB, mitochondrial]: Mitochondrion.
  • 蛋白家族：
    HscB family
  • 组织特异性：
    Expressed in lung, brain, stomach, spleen, ovary, testis, liver, muscle and heart.
  • 数据库链接：

    HGNC: 28913

    OMIM: 608142

    KEGG: hsa:150274

    STRING: 9606.ENSP00000216027

    UniGene: Hs.632780