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HSD17B8 Antibody

  • 货号：
    CSB-PA240849
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA240849(HSD17B8 Antibody) at dilution 1/55, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-3: 293T cells, K562 cells, human fetal liver tissue, Primary antibody: CSB-PA240849(HSD17B8 Antibody) at dilution 1/450, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds
  • 其他：

产品详情

  • Uniprot No.：
    Q92506
  • 基因名：
    HSD17B8
  • 别名：
    17 beta HSD 8 antibody; 17 beta hydroxysteroid dehydrogenase 8 antibody; 17-beta-HSD 8 antibody; 17-beta-hydroxysteroid dehydrogenase 8 antibody; 17-beta-hydroxysteroid dehydrogenase VIII antibody; 3-oxoacyl-[acyl-carrier-protein] reductase antibody; 3-oxoacyl-acyl-carrier protein reductase, E. coli, homolog of antibody; Beta ketoacyl [acyl carrier protein] reductase like antibody; D6S2245E antibody; DHB8_HUMAN antibody; dJ1033B10.9 antibody; Estradiol 17 beta dehydrogenase 8 antibody; Estradiol 17-beta-dehydrogenase 8 antibody; Estrogen 17 oxidoreductase antibody; FABG antibody; FabG, E. coli, homolog of antibody; FabG-like antibody; FABGL antibody; H2 KE6 antibody; H2-KE6 antibody; HKE6 antibody; HSD17B8 antibody; Hydroxysteroid (17 beta) dehydrogenase 8 antibody; Ke-6 antibody; KE6 antibody; KE6, mouse homolog of antibody; Protein Ke6 antibody; Really interesting new gene 2 protein antibody; RING2 antibody; SDR30C1 antibody; Short chain dehydrogenase/reductase family 30C member 1 antibody; Testosterone 17 beta dehydrogenase 8 antibody; Testosterone 17-beta-dehydrogenase 8 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Fusion protein of Human HSD17B8
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
    IHC 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Required for the solubility and assembly of the heterotetramer 3-ketoacyl-[acyl carrier protein] (ACP) reductase functional complex (KAR or KAR1) that forms part of the mitochondrial fatty acid synthase (mtFAS). Alpha-subunit of the KAR complex that acts as a scaffold protein required for the stability of carbonyl reductase type-4 (CBR4, beta-subunit of the KAR complex) and for its 3-ketoacyl-ACP reductase activity, thereby participating in mitochondrial fatty acid biosynthesis. Catalyzes the NAD-dependent conversion of (3R)-3-hydroxyacyl-CoA into 3-ketoacyl-CoA (3-oxoacyl-CoA) with no chain length preference; this enzymatic activity is not needed for the KAR function. Prefers (3R)-3-hydroxyacyl-CoA over (3S)-3-hydroxyacyl-CoA and displays enzymatic activity only in the presence of NAD(+). Cooperates with enoyl-CoA hydratase 1 in mitochondria, together they constitute an alternative route to the auxiliary enzyme pathways for the breakdown of Z-PUFA (cis polyunsaturated fatty acid) enoyl-esters. NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol (17beta-estradiol or E2). Has very low activity towards testosterone and dihydrotestosterone (17beta-hydroxy-5alpha-androstan-3-one). Primarily an oxidative enzyme, it can switch to a reductive mode determined in the appropriate physiologic milieu and catalyze the reduction of estrone (E1) to form biologically active 17beta-estradiol.
  • 基因功能参考文献：
    1. The results indicate that aromatase, 17beta-HSD type 7 and 17beta-HSD type 12, but not 17beta-HSD type 1, are commonly expressed in human breast cancer. PMID: 16930994
    2. transcription in liver is regulated by C/EBPbeta PMID: 17583490
    3. Expression of the human Ke 6 gene, 17beta-hydroxysteroid dehydrogenase type 8, in E. coli and the substrate specificity of the expressed protein were examined. The tissue distribution of mRNA expression of the human Ke 6 gene was also studied. PMID: 17978863
    4. ERalpha is involved in the transcriptional regulation of HSD17B8 gene in response to E2 through its interaction with C/EBPbeta. PMID: 18852215
    5. Hs17beta-HSD8 and HsCBR4 show a strong genetic interaction in vivo in yeast, where, only if they are expressed together, they rescue the respiratory deficiency and restore the lipoic acid content of oar1Delta cells. PMID: 19571038
    6. HSD17B8 mRNA is expressed in human skin, at lower levels in face vs arm or hip. HSD17B8 levels are not altered by topical 17-beta-estradiol treatment. PMID: 18794456

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  • 亚细胞定位：
    Mitochondrion matrix.
  • 蛋白家族：
    Short-chain dehydrogenases/reductases (SDR) family
  • 组织特异性：
    Widely expressed, particularly abundant in prostate, placenta and kidney. Expressed at protein level in various tissues like brain, cerebellum, heart, lung, kidney, ovary, testis, adrenals and prostate.
  • 数据库链接：

    HGNC: 3554

    OMIM: 601417

    KEGG: hsa:7923

    STRING: 9606.ENSP00000363794

    UniGene: Hs.415058