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HSPB7 Antibody

  • 货号：
    CSB-PA10979A0Rb
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using CSB-PA10979A0Rb at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) HSPB7 Polyclonal antibody
  • Uniprot No.：
    Q9UBY9
  • 基因名：
    HSPB7
  • 别名：
    Cardiovascular heat shock protein antibody; cvHsp antibody; DKFZp779D0968 antibody; FLJ32733 antibody; Heat shock 27kda protein family member 7 antibody; Heat shock protein beta 7 antibody; Heat shock protein beta-7 antibody; Hsp25 2 antibody; HspB7 antibody; HSPB7_HUMAN antibody; Hypothetical protein flj34956 antibody; RP11-5P18.6 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Heat shock protein beta-7 protein (1-170AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，HSPB7 Antibody (CSB-PA10979A0Rb)，的标记方式是Non-conjugated。对于HSPB7 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA10979B0Rb HSPB7 Antibody, HRP conjugated ELISA
    FITC CSB-PA10979C0Rb HSPB7 Antibody, FITC conjugated
    Biotin CSB-PA10979D0Rb HSPB7 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 基因功能参考文献：
    1. Loss of Hspb7 in zebrafish or human cardiomyocytes stimulated autophagic pathways and expression of the sister gene encoding Hspb5. Inhibiting autophagy caused FilaminC aggregation in HSPB7 mutant human cardiomyocytes and developmental cardiomyopathy in hspb7 mutant zebrafish embryos. PMID: 29331499
    2. our findings characterize HSPB7 as an intercalated disc protein and suggest it has an essential role in maintaining intercalated disc integrity and conduction function in the adult heart. PMID: 28827800
    3. Patients with central sleep apnea and congestive heart failure had higher T allele frequencies in the HSPB7 gene. PMID: 27441470
    4. HSPB7 loci is associated in the pathophysiologuy of ischemic heart failure. PMID: 25889438
    5. Results imply that HSBP7 is likely to be a tumor suppressor gene regulated by p53 and its downregulation by hypermethylation may play a critical role in renal carcinogenesis. PMID: 24585183
    6. HSPB7 is a potential early biomarker after MI and serves as an independent risk factor of ACS in patients with acute chest pain. PMID: 22785082
    7. Data show a significant association between a SNP in HSPB7 gene (rs1739843, minor allele frequency 39%) and idiopathic DCM. PMID: 20975947
    8. The rs1738943 shows that although this SNP is located within HSPB7, it resides in a block of high LD that spans HSPB7 and a nearby gene, CLCNKA, which encodes a voltage-sensitive chloride channel expressed mainly in the kidney. PMID: 20124441
    9. Cardiac signaling genes exhibit unexpected sequence diversity in sporadic cardiomyopathy, revealing HSPB7 polymorphisms associated with disease. PMID: 20038796
    10. HSPB7 constitutively localized to SC35 splicing speckles, driven by its N-terminus. Unlike HSPB1 and HSPB5, that chaperoned heat unfolded substrates and kept them folding competent, HSPB7 did not support refolding. PMID: 19464326

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  • 亚细胞定位：
    Cytoplasm. Nucleus. Nucleus, Cajal body. Note=Resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles.
  • 蛋白家族：
    Small heat shock protein (HSP20) family
  • 组织特异性：
    Isoform 1 is highly expressed in adult and fetal heart, skeletal muscle, and at a much lower levels in adipose tissue and in aorta. Undetectable in other tissues. Isoform 2 and isoform 3 are poorly detected in heart.
  • 数据库链接：

    HGNC: 5249

    OMIM: 610692

    KEGG: hsa:27129

    STRING: 9606.ENSP00000310111

    UniGene: Hs.502612