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HTN3 Antibody

  • 货号：
    CSB-PA010879NA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA010879NA01HU diluted at 1:100 and staining in paraffin-embedded human salivary gland tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG labeled by HRP and visualized using 0.05% DAB.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) HTN3 Polyclonal antibody
  • Uniprot No.：
    P15516
  • 基因名：
    HTN3
  • 别名：
    HTN3 antibody; HIS2 antibody; Histatin-3 antibody; Basic histidine-rich protein antibody; Hst antibody; Histidine-rich protein 3 antibody; PB) [Cleaved into: Histatin-3; His3-(20-44)-peptide antibody; His3 20/44 antibody; His3-(1-25)-peptide antibody; His3 1/25 antibody; Histatin-3 1/25 antibody; Histatin-6); His3-(20-43)-peptide antibody; His3 20/43 antibody; His3-(1-24)-peptide antibody; His3 1/24 antibody; Histatin-3 1/24 antibody; Histatin-5); His3-(20-32)-peptide antibody; His3 20/32 antibody; His3-(1-13)-peptide antibody; His3 1/13 antibody; Histatin-3 1/13); His3-(20-31)-peptide antibody; His3 20/31 antibody; His3-(1-12)-peptide antibody; His3 1/12 antibody; Histatin-3 1/12); His3-(20-30)-peptide antibody; His3 20/30 antibody; His3-(1-11)-peptide antibody; His3 1/11 antibody; Histatin-3 1/11); His3-(24-32)-peptide antibody; His3 24/32 antibody; His3-(5-13)-peptide antibody; His3 5/13 antibody; Histatin-3 5/13); His3-(24-31)-peptide antibody; His3 24/31 antibody; His3-(5-12)-peptide antibody; His3 5/12 antibody; Histatin-11 antibody; Histatin-3 5/12); His3-(24-30)-peptide antibody; His3 24/30 antibody; His3-(5-11)-peptide antibody; His3 5/11 antibody; Histatin-12 antibody; Histatin-3 5/11); His3-(25-32)-peptide antibody; His3 25/32 antibody; His3-(6-13)-peptide antibody; His3 6/13 antibody; Histatin-3 6/13); His3-(25-30)-peptide antibody; His3 25/30 antibody; His3-(6-11)-peptide antibody; His3 6/11 antibody; Histatin-3 6/11); His3-(26-32)-peptide antibody; His3 26/32 antibody; His3-(7-13)-peptide antibody; His3 7/13 antibody; Histatin-3 7/13); His3-(26-31)-peptide antibody; His3 26/31 antibody; His3-(7-12)-peptide antibody; His3 7/12 antibody; Histatin-3 7/12); His3-(26-30)-peptide antibody; His3 26/30 antibody; His3-(7-11)-peptide antibody; His3 7/11 antibody; Histatin-3 7/11); His3-(31-51)-peptide antibody; His3 31/51 antibody; His3-(12-32)-peptide antibody; His3 12/32 antibody; Histatin-3 12/32 antibody; Histatin-4); His3-(31-44)-peptide antibody; His3 31/44 antibody; His3-(12-25)-peptide antibody; His3 12/25 antibody; Histatin-3 12/25 antibody; Histatin-9); His3-(31-43)-peptide antibody; His3 31/43 antibody; His3-(12-24)-peptide antibody; His3 12/24 antibody; Histatin-3 12/24 antibody; Histatin-7); His3-(32-44)-peptide antibody; His3 32/44 antibody; His3-(13-25)-peptide antibody; His3 13/25 antibody; Histatin-10 antibody; Histatin-3 13/25); His3-(32-43)-peptide antibody; His3 32-43 antibody; His3-(13-24)-peptide antibody; His3 13/24 antibody; Histatin-3 13/24 antibody; Histatin-8); His3-(33-44)-peptide antibody; His3 33/44 antibody; His3-(14-25)-peptide antibody; His3 14/25 antibody; Histatin-3 14/25); His3-(33-43)-peptide antibody; His3 33/43 antibody; His3-(14-24)-peptide antibody; His3 14/24 antibody; Histatin-3 14/24); His3-(34-44)-peptide antibody; His3 34/44 antibody; His3-(15-25)-peptide antibody; His3 15/25 antibody; Histatin-3 15/25); His3-(34-43)-peptide antibody; His3 34/43 antibody; His3-(15-24)-peptide antibody; His3 15/24 antibody; Histatin-3 15/24); His3-(45-51)-peptide antibody; His3 45/51 antibody; His3-(26-32)-peptide antibody; His3 26/32 antibody; Histatin-3 26/32); His3-(47-51)-peptide antibody; His3 47/51 antibody; His3-(28-32)-peptide antibody; His3 28/32 antibody; Histatin-3 28/32); His3-(48-51)-peptide antibody; His3 48/51 antibody; His3-(29-32)-peptide antibody; His3 29/32 antibody; Histatin-3 29/32)] antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Peptide sequence from Human Histatin-3 protein (20-34AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，HTN3 Antibody (CSB-PA010879NA01HU)，的标记方式是Non-conjugated。对于HTN3 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA010879NB01HU HTN3 Antibody, HRP conjugated ELISA
    FITC CSB-PA010879NC01HU HTN3 Antibody, FITC conjugated
    Biotin CSB-PA010879ND01HU HTN3 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Antigen Affinity purified & Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:100-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Histatins are salivary proteins that are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). In addition, histatins exhibit antibacterial and antifungal activities. His3-(20-43)-peptide (histatin-5) is especially effective against C.albicans and C.neoformans, and inhibits Lys-gingipain and Arg-gingipain (rgpB) from P.gingivalis. In addition, His3-(20-43)-peptide is a potent inhibitor of metalloproteinases MMP2 and MMP9.
  • 基因功能参考文献：
    1. This aim of this study was to identify novel biomarkers using comparative global proteome analysis to improve the risk assessment for recurrent coronary events. Beta -defensin-128 and histatin-3 may be potential biomarkers whch may be used to improve risk the stratification for recurrent coronary events. PMID: 28627688
    2. the availability of Cu during exposure of Candida albicans to histatin-5 (Hist-5) modulates its antifungal activity. PMID: 28763199
    3. The aim of this study was to achieve a molecular understanding and a physico-chemical insight of the obtained small angle X-ray scattering and to gain information of the conformational changes of Histatin 5 due to altering salt content, charge distribution, and net charge. PMID: 26914439
    4. Histatin 5 Salivary Complexes PMID: 26544073
    5. Hst 5 may affect mitochondrial functions and cause oxidative stress; however, the ultimate cause of cell death is by volume dysregulation and ion imbalance triggered by osmotic stress. [Review] PMID: 24951439
    6. High intensity of caries is associated with increased levels of some salivary components - sIgA, histatin-5 and lactoperoxidase. PMID: 24974109
    7. analysis of histatin 5 uptake by Candida albicans utilizes polyamine transporters Dur3 and Dur31 proteins PMID: 22033918
    8. Histatin-5 is a likely transport molecule for toxic Ni(II) in human saliva.Its binding constant to nickel is five time higher than that of albumin. PMID: 21741339
    9. Hst 5 binding to beta-glucans on the cell wall of C. albicans is salt-sensitive. Uptake of Hst 5 shows dose-dependent translocation and intracellular accumulation precede vacuole expansion and propidium iodide uptake. PMID: 20487276
    10. Killing of Candida albicans requires cellular uptake and energy metabolism (Histatin 5) PMID: 11816973
    11. caused a loss of cell viability concomitant with a decrease in cellular volume as determined both by a classical candidacidal assay with exogenous Hst 5 and by using a genetically engineered C. albicans strain expressing Hst 5 (salivary histatin 5) PMID: 12183519
    12. study provides evidence for a novel function for yeast Ssa1/2 heat-shock proteins as cell envelope binding receptors for histatin 5 that mediate fungicidal activity PMID: 12761219
    13. results suggest that the genesis of histatin 3-related peptides, being under the principal action of trypsin-like activities, is probably not a random process but rather follows a sequential fragmentation pathway; cleavage sites are identified PMID: 15272024
    14. A 20-residue-derived histatin 5 peptide preserves anticandidal activity, binds DNA, and has nuclease activity in the presence of copper and zinc ions. PMID: 17176059
    15. Two cationic lysine residues at positions 2 and 10 in the P-113 peptide of Histatin 5 are important for transport into the cytosol of Candida albicans and that binding and transport are independent functional events. PMID: 17999963
    16. key steps of its lethal mechanism against parasites PMID: 18230684
    17. Gene polymorphism at codon 23 of the histatin 3 gene was not associated with periodontitis in the Japanese population. Rather it appeared to be associated with resistance to periodontitis. PMID: 19753800

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  • 亚细胞定位：
    Secreted. Note=Secreted by serous acinar and demilune cells.
  • 蛋白家族：
    Histatin/statherin family
  • 数据库链接：

    HGNC: 5284

    OMIM: 142702

    KEGG: hsa:3347

    STRING: 9606.ENSP00000432561

    UniGene: Hs.654442