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HTRA3 Antibody

  • 货号：
    CSB-PA596009
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA596009(HTRA3 Antibody) at dilution 1/45, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    P83110
  • 基因名：
    HTRA3
  • 别名：
    High temperature requirement factor A3 antibody; High-temperature requirement factor A3 antibody; HtrA serine peptidase 3 antibody; HTRA3 antibody; HTRA3_HUMAN antibody; Pregnancy related serine protease antibody; Pregnancy-related serine protease antibody; Probable serine protease HTRA3 antibody; PRSP antibody; Serine protease HTRA3 antibody; Tasp antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic peptide of Human HTRA3
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:5000
    IHC 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits signaling mediated by TGF-beta family proteins possibly indirectly by degradation of these ECM proteoglycans. May act as a tumor suppressor. Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the development of the placenta in vivo. May also have a role in ovarian development, granulosa cell differentiation and luteinization.
  • 基因功能参考文献：
    1. Our findings demonstrated a novel pro-apoptotic role of HTRA3 in pancreatic cancer cells via inducing Bax. PMID: 28860718
    2. HTRA3 suppresses tumor cell invasiveness and may serve as a prognostic biomarker for postoperative recurrence or survival in NSCLC PMID: 27166271
    3. Removal of the 6 additional LB loop residues caused a complete loss of the proper trimeric structure. Impairing their interactions with the PDZ domain decreased the amount of the trimers. The LB loop helps stabilize the DeltaN-HtrA3L oligomer structure suggesting involvement of the LB-PDZ interactions in the stabilization. A monomeric form of the DeltaN-HtrA3L is proteolytically inactive. PMID: 28642151
    4. HtrA3 expression in the peritumoral stroma of patients with stage II colorectal cancer is associated with high-grade tumor budding and may be a novel marker of poor outcome. PMID: 28716573
    5. New insights into the structure and function of DeltaN-HtrA3, which seems to have a unique combination of features among human HtrA proteases. PMID: 26110759
    6. HtrA3 is likely to be associated with the acquisition of the invasive phenotype in oral squamous cell carcinoma cells and may be a potential prognostic marker for oral cance PMID: 25456008
    7. HtrA1 and HtrA3 are crucial for trophoblast-decidual cell interaction in the control of trophoblast invasion. PMID: 25002585
    8. Data indicate that the levels of high temperature requirement factor A3 (HtrA3)protein were lower in all subtypes of ovarian cancer and the lowest levels of HtrA3 were in epithelial ovarian cancer. PMID: 25274382
    9. Data indicate that in breast cancers with no lymphatic metastasis, the expression of HtrA3 was lower in patients with estrogen receptor (ER)- and progesterone receptor (PR)-positive tumors. PMID: 23812730
    10. HtrA3 may have a role as an early marker for preeclampsia PMID: 23049902
    11. results suggest that HtrA3 variants may play different roles in cancer development, and that the increased HtrA3-L levels in thyroid tissue could be correlated with the development of malignant lesions PMID: 22923201
    12. HTRA3 is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells. PMID: 21555518
    13. decidual HtrA3 negatively regulates trophoblast invasion PMID: 21321049
    14. inhibitor of trophoblast invasion during placental development PMID: 21035848
    15. Abnormally high levels of serum HtrA3 at approximately 13-14 wk of gestation is associated with preeclampsia PMID: 21047919
    16. role of HtrA3 (along with HtrA1 and HtrA2) in development/progression of cancer, neurodegenerative disorders and arthritic diseases [REVIEW] PMID: 20469960
    17. critical for normal placental development; different expression profile during abnormal pregnancy PMID: 19359045
    18. HtrA3 may be a previously uncharacterized mitochondrial cell death effector whose serine protease function may be crucial to modulating etoposide- and cisplatin-induced cytotoxicity in lung cancer cell lines. PMID: 20154083
    19. these data indicate that 15dPGJ2 is able to stimulate the expression of HtrA3 through an indirect mechanism involving the MEK/ERK pathway but independent of PPARgamma. PMID: 19951697
    20. cigarette smoke-induced methylation of HtrA3 could contribute to the etiology of chemoresistant disease in smoking-related lung cancer. PMID: 20068077
    21. We cloned the full-length sequences of two forms (long and short) of human HtrA3 mRNA, located the gene on chromosome 4p16.1, determined its genomic structure and revealed how the two mRNA variants are produced through alternative splicing PMID: 12513693
    22. Upregulation of HTRA3 expression in association with placental development was revealed by a significant elevation of this protein in the maternal serum during the first trimester PMID: 16251496
    23. RT-PCR analysis showed a significant reduction of HTRA1 and HTRA3 mRNA in endometrial cancer compared to normal endometrium. HTRA1 and HTRA3 protein showed a similar pattern of expression in EC tissue. PMID: 16650464
    24. Structural and functional analysis of the PDZ domains of human HtrA1 and HtrA3 PMID: 17962403
    25. In ovarian cancer there is a dramatic decrease of HtrA3 mRNA and protein levels in all ovarian tumor groups; HtrA3 may function as a tumor suppressor. PMID: 18241672
    26. HtrA3 was down-regulated in endometrial cancers. PMID: 19424634

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  • 亚细胞定位：
    Secreted. Note=Secretion increased during decidualization of endometrial stromal cells.
  • 蛋白家族：
    Peptidase S1C family
  • 组织特异性：
    Widely expressed, with highest levels in both adult and fetal heart, ovary, uterus placenta, and bladder. In the endometrium, expressed in epithelial glands and the stroma. Also present in leukocytes. Isoform 1 is predominant in heart and skeletal muscle,
  • 数据库链接：

    HGNC: 30406

    OMIM: 608785

    KEGG: hsa:94031

    STRING: 9606.ENSP00000303766

    UniGene: Hs.479119