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Hp Antibody

  • 货号：
    CSB-PA17069A0Rb
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: Hp antibody at 2µg/ml + Rat live tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 39, 43 kDa
      Observed band size: 39 kDa
    • Immunohistochemistry of paraffin-embedded mouse liver tissue using CSB-PA17069A0Rb at dilution of 1:50
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Rattus norvegicus (Rat) Hp Polyclonal antibody
  • Uniprot No.：
    P06866
  • 基因名：
  • 别名：
    Hp antibody; Ba1-647 antibody; Haptoglobin antibody; Liver regeneration-related protein LRRG173) [Cleaved into: Haptoglobin alpha chain; Haptoglobin beta chain] antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Rat
  • 免疫原：
    Recombinant Rat Haptoglobin protein (19-346AA)
  • 免疫原种属：
    Rattus norvegicus (Rat)
  • 标记方式：
    Non-conjugated

    本页面中的产品，Hp Antibody (CSB-PA17069A0Rb)，的标记方式是Non-conjugated。对于Hp Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA17069B0Rb Hp Antibody, HRP conjugated ELISA
    FITC CSB-PA17069C0Rb Hp Antibody, FITC conjugated
    Biotin CSB-PA17069D0Rb Hp Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway.
  • 基因功能参考文献：
    1. This study demonistrated that increased Hp in serum came from the liver in response to TBI and that IL-6 is an important mediator of this induction. PMID: 23172820
    2. Vaccenic acid normalizes serum haptoglobin in obese/insulin resistant JCR:LA-cp rats PMID: 22254015
    3. activated glucocorticoid receptor through direct interactions with STAT3 and C/EBPbeta, participates in Hp gene upregulation as a transcriptional coactivator. PMID: 20155810
    4. Haptoglobin deficiency worsens intracerebral hemorrhage whereas haptoglobin overexpression alleviates intracerebral hemorrhage-mediated brain injury. PMID: 20016097
    5. Hp-mediated haemoglobin catabolism in lung cells may be an efficient mechanism to reduce oxidative damage associated with haemolysis PMID: 11865979
    6. Haptoglobin gene expression regulation PMID: 11865981
    7. Hp is transcriptionally modulated throughout prenatal hepatic development by fetal p53 protein. PMID: 11991649
    8. upregulated in reactive astrocytes after transient forebrain ischemia in rats PMID: 12368655
    9. Hp gene transcription is regulated by C/EBP alpha during normal liver development, whereas C/EBP beta is involved in the acute-phase response regulation during the later phase of differentiation and in the adult. PMID: 16172914
    10. Western blotting and enzyme-linked immunosorbent assay clearly showed a markedly increased level of Hp in the urine, but not in the serum, of the PHN animals. PMID: 17616219
    11. that interactions between C/EBPs and HDAC1 negatively regulate C/EBPdelta-dependent haptoglobin expression in intestinal epithelial cells. PMID: 17910034
    12. lamin components of the nuclear matrix form a network of functional, dynamic protein-protein and protein-Hp-S/MAR associations with multiple partners, and underline the involvement of PARP-1 in the regulation of haptoglobin gene transcription. PMID: 19521970
    13. Data concluded that haptoglobin gene up-regulation during chronic dietary restriction was regulated by different mechanisms than during the acute phase response. PMID: 19545490

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Peptidase S1 family
  • 组织特异性：
    Expressed by the liver and secreted in plasma.
  • 数据库链接：

    KEGG: rno:24464

    UniGene: Rn.10950